妊娠期生殖道B族链球菌对胎膜早破及妊娠结局影响

The influence of group B streptococcal caused reproductive tract infection of pregnant women on their premature rupture of membranes and pregnancy outcomes

目的:探讨妊娠期生殖道B族链球菌感染与胎膜早破及对妊娠结局影响。方法:选取本院2016年4月—2018年4月就诊的胎膜早破患者80例为观察组,同期住院正常孕妇80例为对照组,均行阴道和肛拭子实时定量PCR生殖道B族链球菌(GBS)感染检测,观察妊娠结局及新生儿情况。结果:观察组GBS阳性率(18.8%)高于对照组(5.0%)(P<0.05);观察组GBS阳性孕妇发生新生儿肺炎(6.7%)、胎儿窘迫(26.7%)以及绒毛膜羊膜炎(20.0%)比例高于GBS阴性孕妇,剖宫产(33.3%)、产后出血(13.3%)、早产(6.7%)以及新生儿黄疸(13.3%)、窒息(6.7%)、GBS感染(6.7%)的发生率均高于对照组,新生儿体质量和Apgar评分低于对照组(均P<0.05)。结论:妊娠期生殖道B族链球菌感染与胎膜早破有关,对妊娠结局可造成不利影响。

Objective:To investigate the influence of group B streptococcal(GBS)caused reproductive tract infection of pregnant women on their premature rupture of membranes(PROM)and pregnancy outcomes.Methods:80 pregnant women with PROM were randomly selected into the study group from April 2016 to April 2018,and other normal pregnant women were selected into the control group during the same time.The GBS samples came from vaginal and anal swabs of all women in the both groups were detected by real-time quantitative PCR.The prognosis of neonates born and pregnancy outcomes was observed.Results:The positive rate of GBS of women in the study group was 18.8%,which was significant higher than that(5.0%)of women in the control group(P<0.05).In the study group,the incidences of neonatal pneumonia,fetal distress and chorioamnionitis of women with GBS positive were 6.7%,26.7%,and 20.0%,respectively,which were significant higher than those of women with GBS negative(P<0.05).The incidences of cesarean section,postpartum hemorrhage,premature delivery of women,and the jaundice,asphyxia,and GBS infection of newborn in the study group were 33.3%,13.3%,6.7%,13.3%,6.7%,and 6.7%,respectively,which were significant higher than those in the control group(P<0.05),but the incidence of body weight and Apgar score of newborn in the study group were significant lower than those of women in the control group(P<0.05).Conclusion:Group B streptococcus caused reproductive tract infection during pregnancy is closely related to premature rupture of membranes,which can lead to adverse pregnancy outcomes.