血清PRL、β-hCG及CA125联合检测预测先兆流产保胎治疗结局

Combined detection of serum PRL, beta-HCG and CA125 levels to predict the outcomes of women with threatened abortion

目的:探讨血清泌乳素(PRL)、β-人绒毛膜促性腺激素(β-hCG)、血清糖链蛋白125(CA125)联合检测对先兆流产保胎治疗结局的预测价值。方法:收集136例先兆流产孕妇,根据妊娠结局的不同分为继续妊娠组110例、难免流产组26例,另选取同期接诊的80例正常孕妇为对照组。均检测血清PRL、β-hCG、CA125,分析3项联合检测对先兆流产结局的预测价值。结果:先兆流产者血清PRL、β-hCG水平低于对照组,CA125水平高于对照组,且难免流产组的PRL、β-hCG水平低于继续妊娠组,CA125水平高于继续妊娠组(均P<0.05)。难免流产组孕5、7、9周时血清PRL、β-hCG水平均低于继续妊娠组,CA125水平高于继续妊娠组(均P<0.05)。PRL、β-hCG、CA125联合检验诊断先兆流产保胎治疗后难免流产的敏感性、特异性、准确性分别为89.2%、93.4%、89.9%,高于PRL、β-hCG、CA125单独检测(P<0.05)。结论:妊娠早期对先兆流产者联合检测血清PRL、β-hCG、CA125,有较高的预测难免流产价值。

Objective:To investigate the predictive value of combined detection of serum prolactin(PRL),beta-human chorionic gonadotropin(β-HCG),and serum glycoprotein 125(CA125)levels for the outcomes of women with threatened abortion after spuc treatment.Methods:136 pregnant women with threatened abortion were divided into group A(110 women with continuous pregnancy)and group B(26 women with inevitable abortion),and other 80 normal pregnant women were selected in group C.All included women were received serum PRL,β-HCG and CA125 levels detected,and the predictive value of combined detection of serum PRL,β-HCG and CA125 for the outcomes of women with threatened abortion after spuc treatment were analyzed.Results:The serum levels of PRL andβ-HCG of women in group A and B were significant lower than those of women in group C,and those of women in group A were significant lower than those of women in group B,but the level of CA125 of women in group A and B was significant higher than that of women in group C(P<0.05).The levels of PRL and-HCG of women in 5,7 and 9 gestational weeks in group A were significant lower than those of women in group B,but the level of CA125 of women in group A and B was still significant higher than that of women in group C(P<0.05).The sensitivity,specificity and accuracy of combined detection of PRL,β-HCG and CA125 levels for diagnosing inevitable abortion of women with threatened abortion after spuc treatment were 89.2%,93.4%and 89.9%,respectively,which were significant higher than those of level detection of PRL,beta-HCG or CA125 alone(P<0.05).Conclusion:Combined detection of serum PRL,β-HCG and CA125 levels of women with threatened abortion during the first trimester pregnancy has high predictive value for inevitable abortion.