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红霉素A9-肟羟基的醚化保护 被引量：5

Etherification Protection for Hydroxyls in Erythromycin A Oximes
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摘要 用 3种烷氧基环己烯 (1-异丙氧基环己烯、1-乙氧基环己烯和 1-甲氧基环己烯 )对红霉素肟的羟基加以保护 ,同时与醚化剂 2 -乙氧基丙烯作了比较 .反应在二氯甲烷中进行 ,盐酸吡啶作催化剂 .实验发现 ,1-异丙氧基环己烯和 1-乙氧基环己烯的保护比较完全 ,并对后者进行了工艺研究 . Three kinds of alkyloxy cyclohexene, viz. 1-isopropoxycyclohexene, 1-ethoxycyclohexene and 1-methoxycyclohexene, were investigated for hydroxyl protection in erythromycin oxime. The obtained results showed that 1-isopropoxycyclohexene and 1-ethoxycyclohexene were potential protective reagents in clarithromycin synthesis.
作者 梁建华 邓志华 孙京国 林美娜 姚国伟
机构地区 北京理工大学生命科学与技术学院
出处 《北京理工大学学报》 EI CAS CSCD 北大核心 2003年第1期120-122,132,共4页 Transactions of Beijing Institute of Technology
基金 国家经贸委技术创新项目 ( 0 1BK-0 0 9)
关键词 红霉素A9-肟 羟基 保护 克拉霉素 醚化剂 合成 大环内酯抗生素 烷氧基环己烯 2-乙氧基丙烯 clarithromycin erythromycin etherification synthesis
分类号 TQ465.5 [化学工程—制药化工]
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参考文献10

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二级参考文献1

共引文献2

同被引文献44

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引证文献5

二级引证文献18

北京理工大学学报
2003年 第1期

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