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Kail/CD_(82)在膀胱癌中的表达及其临床意义

Expression of Kail/CD_(82) and Its Clinical Value in Bladder Carcinoma
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摘要 目的 :探讨Kail CD82 表达与膀胱癌的病理分级、临床分期、转移及预后的关系。方法 :应用免疫组化SP法研究 6 0例膀胱癌组织的Kail CD82 的表达。结果 :Ⅰ、Ⅱ、Ⅲ级膀胱癌中Kail CD82 的阳性表达率分别为 86 .7%、6 0 %、30 %。膀胱癌Kail CD82 的表达与肿瘤病理分级呈负相关 (P <0 .0 1)。膀胱癌Ta T1 组表达率为 86 .7% ,而T2 T4 组表达率为 5 0 % ,两组间差异有显著性 (P <0 .0 1)。浸润和转移组阳性表达率明显低于无浸润、转移组 (33.3%vs80 % ,P <0 .0 1)。结论 :Kail CD82 与膀胱癌的浸润及转移有关。在膀胱癌中 ,Kail CD82 可能是一种肿瘤转移抑制因子。 Objective: To investigate the expression of Kail/CD 82 and its correlation with pathological grade, clinical stage, metastasis, and prognosis in bladder carcinoma.Methods:Expression of Kail/CD 82 in 60 cases of bladder carcinoma was studied by means of S P immunohistochemistry. Results:The positive rate in Ⅰ?Ⅱ?Ⅲ bladder carcinoma were 86.7%?60%?and 30%,respectively.The expression of Kail/CD 82 in bladder carcinoma correlated inversely to pathological grade( P <0.01). The positive rate in the T a T 1 group of bladder carcinoma was 86.7%,while that was 50% in the T 2 T 4 group. There was obvious difference between the groups( P <0.01).The positive rate of the group with invasion and metastasis was obviously lower than that of ones without invasion and metastasis(33.3% vs. 80%, P <0.01).Conclusion:Kail/CD 82 was correlated to the invasion and metastasis of bladder carcinoma.Kail/CD 82 might be a metastasis suppressor factor in bladder carcinoma.
出处 《江西医学院学报》 2003年第1期45-47,共3页 Acta Academiae Medicinae Jiangxi
关键词 膀胱癌 KAIL/CD82 免疫组化 bladder carcinoma Kail/CD 82 immunohistochemistry
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