60例青少年强迫症患者服用盐酸帕罗西汀联合心理干预的效果研究

The effect of paroxetine hydrochloride combined with psychological intervention in 60 adolescents with obsessive-compulsive disorder

目的:探讨盐酸帕罗西汀联合心理干预在青少年强迫症患者中应用效果。方法:选取我院119例青少年强迫症患者,按照随机双盲法分组,对照组59例采用盐酸帕罗西汀治疗,观察组60例于对照组基础上实施心理干预,观察比较两组干预前后耶鲁-布朗强迫量表(Y-BOCS)评分及干预效果,并统计两组患者满意度及生活质量。结果:干预3个月后观察组强迫行为因子评分、强迫思维因子评分及Y-BOCS总分低于对照组,差异具有统计学意义(t=-2.753,-3.361,-4.382;P<0.01);观察组干预总有效率为88.33%(53/60),高于对照组61.02%(36/59),差异具有统计学意义(χ~2=11.773,P<0.001);观察组患者满意度为91.67%(55/60),高于对照组69.49%(41/59),差异具有统计学意义(χ~2=9.382,P<0.01);观察组干预3个月后生理功能、情感精神、社会功能及躯体功能各维度生活质量评分高于对照组,差异具有统计学意义(t=6.841,5.731,6.133,6.662;P<0.01)。结论:心理干预联合盐酸帕罗西汀有助于改善青少年强迫症状及生活质量,效果显著,患者满意度高。

Objective:To investigate the application effect of paroxetine hydrochloride combined with psychological intervention in adolescents with obsessive-compulsive disorder.Methods:A total of 119 cases of adolescents with obsessive-compulsive disorder in our hospital were randomly divided into two groups.The control group of 59 cases was treated by paroxetine hydrochloride,and 60 cases in the observation group were given psychological intervention on the basis of the control group.The Yale Brown’s Compulsive Scale(Y-BOCS)score and the effect of intervention of two groups before and after intervention were observed and compared.The patients’satisfaction and quality of life two of groups were recorded.Results:After 3 months of intervention,the score of compulsive behavior factor,the score of forced thinking factor and the total score of Y-BOCS of the observation group were lower than those of the control group.The differences were statistically significant(t=-2.753,-3.361,-4.382;P<0.01).The total effective rate of intervention of the observation group was 88.33%(53/60),which was higher than that of the control group[61.02%(36/59)](χ~2=11.773,P<0.001).The patients’satisfaction of the observation group was 91.67%(55/60),which was higher than that of the control group[69.49%(41/59)],and the difference was statistically significant(χ~2=9.382,P<0.01).After 3 months of intervention,the scores of life quality in all dimensions of physiological function,emotional and social function and physical function were significantly higher in the observation group than in the control group,and the differences were statistically significant(t=6.841,5.731,6.133,6.662;P<0.01).Conclusion:Psychological intervention combined with paroxetine hydrochloride can help to improve the compulsive symptoms and quality of life of adolescents with obsessive-compulsive disorder.The effect is significant and the patient’s satisfaction is high.