心理行为干预辅助药物治疗对宫颈高危型人乳头瘤病毒感染治疗效果及心理状态的影响

Effects of psychological and behavioral intervention and drug therapy on the treatment effect and psychological status of high risk HPV infection in cervix

目的:分析心理行为干预辅助药物(重组人干扰素a2b栓)治疗在宫颈高危型人乳头瘤病毒(HPV)感染中的治疗效果及心理状态。方法:回顾性分析2015年1月-2016年7月来我院就诊的宫颈高危型HPV感染的68例女性患者临床资料,根据干预方式分为观察组和对照组各34例。对照组采用一般干预方式联合药物治疗,观察组采用心理行为干预联合药物治疗。比较两组患者HPV DNA负荷量、HPV转阴率、总有效率、SDS和SAS评分。结果:观察组经治疗4个疗程和3个月后其HPV DNA负荷量均低于对照组,两组比较差异间具有统计学意义(t=-3.725,-4.954;P<0.001);观察组与对照组HPV转阴率比较两组差异间具有统计学意义(χ~2=4.836,P=0.028);观察组与对照组的临床总有效率比较差异间具有统计学意义(χ~2=4.221,P=0.040);观察组SDS和SAS评分均低于对照组,两组比较差异间具有统计学意义(t=-8.728,-9.770;P<0.001)。结论:心理行为干预和药物治疗可以提高宫颈高危型HPV感染的转阴率,减少患者的负性情绪,提高患者对治疗的积极性。

Objective:To analyze the efficacy and psychological status of psychological behavioral intervention drugs(recombinant human interferon A2 B suppository)in the treatment of high-risk human papillomavirus(HPV)infection in cervical cancer.Methods:The clinical data of 68 female patients with high-risk HPV infection in our hospital from January 2015 to December 2016 were retrospectively analyzed,according to the nursing methods,the patients were divided into observation group and control group,each with 34 cases.The control group was treated with general care and drug therapy,and the observation group was treated with psychological and behavioral intervention combined with drug treatment.We compared the HPV,DNA load,HPV negative rate,total effective rate,SDS and SAS scores between the two groups.Results:The HPV and DNA load of the observation group after treatment for 4 courses and 3 months were lower than those of the control group,the difference between the two groups was statistically significant(t=-3.725,-4.954;P<0.001);The negative rate of HPV in the observation group and the control group was statistically significant different(χ~2=4.836,P<0.05);The total effective rate of the observation group was statistically significantly different from that of the control group(χ~2=4.221,P<0.05).The scores of SDS and SAS in the observation group were lower than those in the control group,and the difference between the two groups was statistically significant(t=-8.728,-9.770;P<0.001).Conclusion:Psychological behavior intervention and drug treatment can improve the negative rate of high-risk HPV infection in cervix,reduce the negative emotions of patients,improve the enthusiasm of patients for treatment.