比索洛尔配合步行运动训练对充血性心力衰竭患者心功能、负性情绪及生活质量的影响

Effects of bisoprolol combined with walking exercise training on cardiac function,negative emotions and quality of life in patients with congestive heart failure

目的:比索洛尔配合步行运动训练对充血性心力衰竭(CHF)患者心功能、负性情绪及生活质量的影响。方法:回顾性分析2014年6月-2017年6月收治的100例CHF患者临床资料,根据治疗方法分为观察组(n=50)和对照组(n=50)。对照组应用常规治疗和步行运动训练,观察组在对照组基础上加用比索洛尔。评估治疗前、治疗6个月后心功能[左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)]、步行距离[6min步行距离(6MWD)]、负性情绪[简明心境状态量表(POMS)]、生活质量[明尼苏达心力衰竭生活质量量(MLHFQ)]。结果:①治疗6个月后,两组LVEF均高于治疗前(t=-17.719,-11.209;P<0.05),两组LVEDD、LVESD均低于治疗前(t=11.602,6.474;P<0.05),观察组变动幅度均大于对照组(t=11.583,7.483;P<0.05);②治疗6个月后,两组6MWD均高于治疗前(t=-11.033,-6.522;P<0.05),观察组增幅大于对照组(t=4.102,P<0.05);③治疗6个月后,两组紧张、愤怒、疲劳、抑郁、慌乱得分均低于治疗前(P<0.05),精力、和自尊感得分均高于治疗前(P<0.05),观察组变动幅度大于对照组(P<0.05);④治疗6月后,两组MLHFQ得分均低于治疗前(t=11.571,9.408;P<0.05),观察组降幅大于对照组(t=-2.580,P<0.05)。结论:比索洛尔配合步行运动训练有利于改善CHF患者心功能、负性情绪及生活质量,临床应用价值较大。

Objective:To explore the effects of bisoprolol combined with walking exercise training on cardiac function,negative emotions and quality of life in patients with congestive heart failure(CHF).Methods:The clinical data of 100 patients with CHF admitted between June 2014 and June 2017 were retrospectively analyzed.According to the treatment methods,they were divided into observation group(n=50)and control group(n=50).Control group was given routine treatment and walking exercise training,and observation group was given bisoprolol on the basis of control group.The cardiac function[left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD)],walking distance[6 min walking distance(6 MWD)],negative emotions[Profile of Mood States(POMS)]and quality of life[Minnesota Living with Heart Failure Questionnaire(MLHFQ)]were assessed before treatment and after 6 months of treatment.Results:After 6 months of treatment,the LVEF in the two groups was higher than that before treatment(t=-17.719,-11.209;P<0.05),and the LVEDD and LVESD were lower than those before treatment(t=11.602,6.474;P<0.05),and the changes in observation group were higher than those in control group(t=11.583,7.483;P<0.05).After 6 months of treatment,the 6 MWD in the two groups was higher than that before treatment(t=-11.033,-6.522;P<0.05),and the increase in observation group was greater than that in control group(t=4.102,P<0.05).After 6 months of treatment,the scores of tension,anger,fatigue,depression and confusion in the two groups were lower than those before treatment(P<0.05),and the scores of energy and self-esteem were higher than those before treatment(P<0.05),and the changes in observation group were greater than those in control group(t=-5.991,-3.121,-5.458,-11.141,5.388,-3.747,3.547;P<0.05).After 6 months of treatment,the MLHFQ scores in the two group were lower than those before treatment(t=11.571,9.408;P<0.05),and the decrease in observation group was greater than that in control group(t=-2.580,P<0.05).Conclusion:Bisoprolol combined with walking exercise training is beneficial to improve cardiac function,negative emotions and quality of life in patients with CHF,and it has great clinical application value.