阶段性心理健康举措对乳腺癌化疗期间心理健康和免疫水平的影响

Effect of phased psychological intervention on mental health and immunity of breast cancer during chemotherapy

目的:探讨阶段性心理健康举措对化疗期间乳腺癌患者的心理障碍及免疫功能调节的影响,以期为临床治疗提供参考。方法:选取我院2017年1-6月在我院接受化疗的乳腺癌患者。根据对患者的疾病指导方式不同将患者分为观察组和对照组,其中观察组患者采用阶段性心理健康举措,对照组患者采用常规指导方案。比较两组患者匹兹堡睡眠治疗指数量表(PSQI)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)量表评分,对比两组血清CD4,CD8,CD4/CD8及IL-8水平。结果:比较两组患者化疗前后PSQI、HAMD、HAMA指标,化疗前,PSQI、HAMD、HAMA指标比较,差异均无统计学意义(P>0.05);化疗后,PSQI、HAMD、HAMA指标比较具有统计学差异(t=-5.142,-5.141,-8.888;P<0.05)。比较两组患者化疗前后CD4+、CD8,CD4/CD8和血清IL-8水平,化疗前两组患者CD4+、IL-8比例比较,差异无统计学意义(P>0.05),化疗后两组患者CD4+、IL-8比例,均下降,差异具有统计学意义(t=3.254,-4.068;P<0.05);化疗前两组患者CD8+比例比较,差异无统计学意义(P>0.05),化疗后均上升,且观察组化疗后高于对照组,比较具有统计学差异(t=3.058,P<0.05);化疗前后两组患者CD4+/CD8+比较,差异均无统计学意义(P>0.05)。结论:阶段性心理健康举措能减轻患者焦虑、抑郁等心理障碍,且可一定程度的增强患者免疫功能。

Objective:To investigate the effect of phased psychological intervention on the psychological disorders and immune function in patients with breast cancer during chemotherapy and to provide reference for clinical treatment.Methods:We selected breast cancer patients undergoing chemotherapy in our hospital from January 2017 to June 2017.The patients were divided into observation group and control group according to different ways of disease guidance.The observation group was guided by phased psychological intervention program,and the control group patients received routine instruction.PSQI,HAMD and HAMA scores of two groups were compared,and the levels of CD4,CD8,CD4/CD8 and IL-8 were compared between the two groups.Results:Before chemotherapy,PSQI,HAMD and HAMA indexes’differences had no statistical significance(P>0.05).After chemotherapy,PSQI,HAMD and HAMA showed statistical differences(t=-5.142,-5.141,-8.888;P<0.05).CD4+,CD8,CD4/CD8 and serum il-8 levels were compared between the two groups before and after chemotherapy.There was no statistically significant difference in the proportion of CD4+and il-8 between the two groups before chemotherapy(P>0.05).After chemotherapy,the proportion of CD4+and il-8 decreased in both groups,and the difference was statistically significant(t=3.254,-4.068;P<0.05).There was no statistically significant difference in the proportion of CD8+in the two groups before chemotherapy(P>0.05),and it increased after chemotherapy,and the observation group was higher than the control group after chemotherapy,showing statistical difference(t=3.058,P<0.05).CD4+/CD8+were compared between the two groups before and after chemotherapy,and the differences were not statistically significant(P>0.05).Conclusion:Phased psychological intervention can reduce anxiety,depression and other psychological disorders in patients,and to some extent,enhance immune function.