COPD患者极量运动后气体交换指标恢复的观察

The Recovery of Gas Exchange Indicators after Maximal Exercise in Chronic Obstructive Pulmonary Disease Patients

目的:探讨慢性支气管炎型与非慢性支气管炎型Copd患者达极量运动后气体交换指标恢复速率是否存在差异。方法:募集37例慢性支气管炎型Copd患者、45例非慢性支气管炎型Copd患者及50例健康志愿者,收集受试者的一般人口学资料,并完成6分钟步行试验、肺功能检查及心肺运动试验。结果:极量运动后,慢性支气管炎组Copd患者摄氧量恢复率(o2/T Slope)、二氧化碳排出量恢复率(Co2/T Slope)及分钟通气量恢复率（e/T Slope）均较非慢性支气管炎型组减慢。多元回归分析示o2/T Slope、Co2/T Slope均与rV/TlC及dlCo相关;而e/T Slope则与rV/TlC相关。结论:与非慢性支气管炎型患者相比,慢性支气管炎型Copd患者达极量运动后气体交换指标恢复减慢。

Objective:To explore the differences between recovery of gas exchange indicators after maximal exercise in chronic obstructive pulmonary disease patients with or without chronic bronchitis.Methods:We conducted spirometry,a 6-min walking distance test,and cardiopulmonary exercise testing in 37 COPD patients with chronic bronchitis,45 COPD patients without chronic bronchitis,and 50 age-matched normal control sub-·jects.Result:Compared to the patients without chronic bronchitis,COPD patients with chronic bronchitis had slower recovery of oxygen uptake(O2/··t slope),carbon dioxide output(CO2/t slope)and minute volume（E/t slope）after maximal exercise.A stepwise multiple linear regression analysis i-···dentified that both O2/t slope and CO2/t slope were related to RV/TLC and DLCO.However,E/t slope was only related to RV/TLC.Conclusion:Compared to the patients without chronic bronchitis,the patients with chronic bronchitis displayed a slower recovery of gas exchange indicators after maximal exercise.