支原体感染对儿童社区获得性肺炎免疫功能影响的研究

Effect of mycoplasma infection on immunologic function in children with community-acquired pneumonia

目的:研究支原体(MP)感染对儿童社区获得性肺炎(CAP)免疫功能的影响,以提高对儿童CAP及MP感染的认识。方法:回顾性分析2014年5月至2016年5月本院儿科CAP患儿161例,根据呼吸道病原体IgM抗体检测结果分为:MP阳性组45例,MP阴性组116例。比较两组患儿入院生命体征、体液免疫指标(IgG、IgA、IgM、补体C3、补体C4)及细胞免疫指标(CD3%、CD4%、CD8%、NK%、CD4/CD8)。结果:161例患儿MP感染总阳性率为28.0%,女孩MP阳性率显著高于男孩(38.8%vs 20.2%,P<0.05);对于体液免疫,MP阳性组IgM高于MP阴性组,有统计学差异(P<0.05),两组细胞免疫指标无统计学差异(P均>0.05)。结论:在儿童CAP中,女孩的MP阳性率高于男孩,而且MP感染主要影响患儿的体液免疫功能。

Objective:To study the effect of mycoplasma(MP)infection on the immunologic function of children with CAP in order to improve the understanding of CAP and MP infection in children.Methods:We retrospectively analyzed 161 cases of pediatric CAP in our hospital from May 2014 to May 2016.According to the results of IgM antibody detection of respiratory pathogens,all children was divided into MP positive group(45cases)and MP negative group(116cases).General situation,humoral immune index(IgG,IgA,IgM,C3 and C4)and cellular immune index(CD3%,CD4%,CD8%,NK% and CD4/CD8)were compared between two groups.Result:The total positive rate of MP infection was 28.0%.MP positive rate of girls was significantly higher than that of boys(38.8% vs 20.2%).For humoral immunity,IgM of MP positive group was higher than that of MP negative group and there was no significant difference in cellular immune indexbetween two groups.Conclusion:In CAP of children,the positive rate of girls was higher than that of boys,and MP infection mainly affected the humoral immune function of the children.