度洛西汀与舍曲林治疗伴有疼痛的老年抑郁症的对照研究

Comparative study of duloxetine and sertraline in the treatment of late-life depression with pain

目的:对度洛西汀与舍曲林应用于伴有疼痛的老年抑郁症患者治疗中的效果进行对比分析。方法:选取126例接受药物治疗的伴有疼痛的老年抑郁症患者,随机分为度洛西汀组和舍曲林组各63例,对两种药物的疗效进行对照研究,观察8周。采用汉密尔顿焦虑量表(HAMD)24项评定临床疗效,研究用疼痛量表(MOSPM)评定疼痛疗效,副反应量表(TESS)评定不良反应。结果:度洛西汀组的临床疗效高于舍曲林组[76.19%vs.65.08%](P<0.05);其MOSPM评分低于舍曲林组[(30.73±13.87)分vs.(37.61±12.74)分](P<0.05);就不良反应发生率而言,两组间差异无显著差异。结论:度洛西汀应用于伴有疼痛的老年抑郁症患者治疗中的效果明显优于舍曲林。

Objective:To compare the efficacy of duloxetine with sertraline on depression in elderly patients with major depressive disorder and pain.Methods:126 elderly patients with depression and pain were randomly divided into sertraline group and duloxetine group of 63 cases,the efficacy of the two drugs were controlled study.All cases were observed for 8 weeks.HAMD-24 and MOSPM were used to evaluate the clinical curative effect;and TESS was applied to assess the adverse reactions.Result:In the total effective rate,more duloxetine-treated patients completed the study[76.19% vs.65.08%].In the MOSPM score,it’s significantly lower than the sertraline group [(30.73±13.87)points vs.(37.61±12.74)points].There’s no significant statistical difference between the incidence of adverse reactions of the two groups.Conclusion:Duloxetine is superior to sertraline in the treatment of late-life depression with pain.