188例患者采用利培酮、氯氮平、喹硫平等精神类药品后出现的毒副反应总结

188 cases were treated by risperidone,clozapine,quetiapine equality psychiatric drug adverse reaction of summary

目的:总结188例患者采用利培酮、氯氮平、喹硫平等精神类药品后出现的毒副反应。方法:收集我院因服用精神类药品出现毒副反应的患者188例,统计药品种类、毒副反应器官、疾病类型。结果:入选的188例患者中,男性患者为138例,女性患者为50例,男性比例高于女性(73.4%比26.6%,P<0.05)。精神疾病类型中精神分裂症比例最高(52.1%),和其他疾病种类比较均有显著差异(P<0.05)。神经系统毒副反应发生率最高(44.7%),与其他系统或器官毒副反应发生率比较有显著差异(P<0.05)。精神类药品中利培酮毒副作用最大,涉及的系统或器官最多。结论:精神类药品毒副反应多,可影响到神经系统、内分泌系统等多个系统及器官。临床中应用精神类药品时应加强监测,并尽量使用毒副作用影响较小的药物进行治疗。

Objective:To summarize the adverse reaction of the patients in 188 patients with risperidone,clozapine and quine.Methods:188cases of adverse reactions were collected in the hospital,including the types of drugs,the types of drugs and the types of diseases.Result:Among 188 patients,138were men,and 50 were women,and men were higher than women(73.4% over 26.6%,P <0.05).The highest rate of schizophrenia(52.1%)in mental illness was significantly different from other diseases(P < 0.05).The incidence of neurotoxicity was highest(44.7%),and there was a significant difference(P < 0.05)in comparison with other system or organ toxicity.Risperidone in psychotropic drugs is the most important,with the most involved systems or organs.Conclusion:There are many kinds of other systems and organs such as nervous system and endocrine system.When applying psychotropic drugs in clinical practice,the monitoring should be strengthened,and the use of toxic side effects should be used to treat the small drugs.