甲氨蝶呤不同给药方式联合宫腔镜治疗瘢痕妊娠的效果研究

The effect of methotrexate on the treatment of scar pregnancy by combined hysteroscopy

目的:探讨对瘢痕妊娠患者行甲氨蝶呤不同给药方式+宫腔镜联合治疗的临床效果。方法:将2016年1月~2017年1月我院收治的84例瘢痕妊娠患者作为研究对象,根据不同给药方法分为肌肉注射组和囊内注射组,各42例。肌肉注射组行肌肉注射甲氨蝶呤+宫腔镜联合治疗,囊内注射组行妊娠囊注射甲氨蝶呤+宫腔镜联合治疗,观察并比较两组不良反应发生几率、各项手术指标的变化情况。结果:囊内注射组的不良反应发生几率3例(7.14%)显著低于肌肉注射组12例(28.57%),囊内注射组的手术时间、月经恢复时间以及住院时间均优于肌肉注射组,P<0.05为差异具有统计学意义。结论:对瘢痕妊娠患者行妊娠囊内注射甲氨蝶呤+宫腔镜联合治疗,能够加快患者的病情恢复,减少不良反应的发生。

Objective:To explore the clinical effect of different administration of methotrexate combined with hysteroscopy in patients with scar pregnancy.Methods:The 84 cases of scar pregnancy treated by our hospital from January 2016 to January 2017 were used as the study subjects,and 42 patients were divided into muscle injection group and cystic injection group according to different drug administration methods.Muscle line group intramuscular injection methotrexate+ hysteroscopy combined treatment,the cyst injection line set of gestational sac injection methotrexate+ hysteroscopy combined treatment,observe and compare the two groups of adverse reaction probability and the change of the operation indexes.Result:The adverse reactions of sac injection group risk in 3 patients(7.14%)is significantly higher than muscle injection group of 12 cases(28.57%),the cyst operation time of injection group,the menstruation recovery time and hospital stay were superior to muscle injection group,P <0.05 for the difference is statistically significant.Conclusion:Injection of methotrexate combined with hysteroscopy in the pregnancy capsule of scar pregnancy can accelerate the patient’s recovery and reduce the occurrence of adverse reactions.