正清风痛宁片结合甲氨蝶呤与非甾体类抗炎药治疗类风湿性关节炎临床疗效观察

The Effects of Zhengqing Fengtongning Tablets,Methotrexate and NSAIDs on Rheumatoid Arthritis

目的:观察正清风痛宁片结合甲氨蝶呤与非甾体类抗炎药治疗类风湿性关节炎的临床疗效。方法:采用随机对照前瞻性研究方法,对68例RA患者分为观察组和对照组,两组在给予甲氨蝶呤与塞来昔布治疗的基础上,观察组加用正清风痛宁片,疗程12周后观察患者临床症状和体征,并作实验室指标测定,评价RA改善情况。结果:观察组的总体临床有效率显著高于对照组(86.83%vs 63.33%),两组治疗后的主要临床症状评分、晨僵时间以及红细胞沉降率(ESR)、类风湿因子(RA)、肿瘤坏死因子(TNF-α)、白细胞介素-1(IL-1)、白细胞计数(WBC)、血小板计数(PLT)和C反应蛋白(CRP)均优于治疗前,并且观察组患者上述指标优于对照组患者。结论:正清风痛宁片结合甲氨蝶呤与非甾体抗炎药治疗类风湿性关节炎的综合疗效较好,值得推广应用。

Objective:To study the clinical efficacy of of combination of Zhengqing Fengtongning Tablet(ZFT),Methotrexate(MTX)and NSAIDs in the treatment of rheumatoid arthritis(RA).Methods:Sixty-eight cases of patients with RA were randomly divided into control group which treated with MTX and Celecoxib,observation group which treated with ZFT,MTX and celecoxib.Clinical efficacy,morning stiff tiime,and laboratory parameters of patients were observed.Result:The clinical efficacy of the two groups were significantly different.The attenuation of clinical symptoms in observation groups were better than that in control group.After treatment,the ESR,RA,TNF-α,IL-1,WBC,PLT and CRP of observation group were better than that in control group.Conclusion:Take the combination of Zhengqing Fengtongning Tablet,MTX and NSAIDs to cure RA had a better clinical efficacy.