期刊文献+

血浆硫氧还蛋白还原酶在淋巴瘤中表达的初步研究

原文传递
导出
摘要 目的:探究血浆硫氧还蛋白还原酶(TrxR)在霍奇金淋巴瘤(hodgkin lymphoma,HL)中表达的的临床意义。方法:选取我院自2017年7月-2018年6月间收治的45例淋巴瘤患者作为观察组研究对象,选取同期进行体检的健康人45例作为对照组,对比两组受检者血浆中TrxR水平差异,分析不同病理分型中TrxR表达的差异。结果:与健康体检者对比HL组患者的TrxR表达量明显较高,组间数据差异有统计学意义(P<0.05);淋巴细胞为主型(LP)、结节硬化型(NS)、混合细胞型(MC)和淋巴细胞削减型(LD)4种临床病理分型中患者的TxrR表达量差异无统计学意义(P >0.05)。结论:TxrR指标可以作为诊断HL的临床指标,但4种病理分型患者血浆中表达量差异不大,不可作为鉴别临床分型的检测指标。
出处 《健康之路》 2018年第9期23-24,共2页 Health Way
基金 潍坊市科技局2017年立项项目,项目编号:2017YX121
  • 相关文献

参考文献4

二级参考文献40

  • 1沈志祥,朱雄增.恶性淋巴瘤[M].北京:人民出版社,2011:701.
  • 2Yoo MH, Xu XM, Carlson BA, et al. Thioredoxin reductase 1 deficien- cy reverses tumor phenotype and tumorigenicity of lung carcinoma cells [ J ]. J Bioi Chem,2006,281 ( 19 ) : 13 005 - 13 008.
  • 3Ueda S,Masutani H, Nakamura H, et al. Redox control of cell death [ J 1. Antioxid Redox Signal, 2002,4 ( 3 ) :405 - 414.
  • 4Tonissen KF, Di Trapani G. Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy[ J]. Mol Nutr Food Res ,2009,53 ( 1 ) : 87 - 103.
  • 5Lincoln DT, Ali Emadi EM, Tonissen KF, et al. The thioredoxin-thiore- doxin reduetase system:over-expression in human cancer[ J ]. Antican- cer Res,2003,23 ( 3 B) :2425 - 2433.
  • 6Raffel J, Bhattacharyya AK, Gallegos A, et al. Increased expression of thioredoxin-1 in human coloreetal cancer is associated with decreased patient survivalI J]. J Lab Clin Med,2003,142 ( 1 ) :46 - 51.
  • 7Hanakawa H, Orita Y, Sato Y, et al. Novel and simple prognostic index tot nasal natural killer/T-cell lymphoma[J]. Head Neck, 2014,36 (4) :551-556.
  • 8Cao J ,Lan SM ,Zhang N ,et al. The efficacy of CHOP regimen-based con- current chemoradiation therapy in patients with nasal extranodal Natural Killer/T-cell lymphoma : a comparison among treatment modalities[J]. Int J Radiat Oncol Biol Phys, 2013,87 (2) : $553.
  • 9Hatayama Y, Aoki M, Kawaguchi H, et al. Impact of dexamethasone, etoposide,ifosfamide and carboplatin as concurrent chemoradiotherapy agents for nasal natural killer/T-cell lymphoma[J]. Mol Clin Oncol, 2013, 1 (4) :680-684.
  • 10Ma X, Guo Y, Pan Z, et al. Radiation therapy alone not inferior to chemora- diation in the patients with stage I nasal natural killer/T-Cell lymphoma[J]. Int J Radiat Oncol Biol Phys, 2015,93 (3) : E451-E452.

共引文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部