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孕激素在绝经后骨质疏松中的作用 被引量:9

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摘要 动物实验和临床研究均证实孕激素可治疗绝经后骨质疏松,并与雌激素有协同作用。孕激素通过成骨细胞上的孕激素受体影响成骨细胞的增殖和分化,加速骨形成;同时竞争糖皮质激素受体及刺激降钙素的分泌,影响骨吸收。
作者 梁敏
出处 《国外医学(内分泌学分册)》 2003年第2期136-138,共3页 Foreign Medical Sciences(Section of Endocrinology)
基金 国家"九五"攻关项目(96-906-05-05) 卫生部临床学科重点建设项目(08-96002-16) 湖南省社会发展科研计划(995SY1009-10)。
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  • 1Dijkema R, Schoonen W G, Teuwen R,et al. Human progesteronereceptor A and B isoforms in CHO cells. I. Stable transfection of receptor and receptor responsive reporter genes: transcription modulation by (anti) progestagens[J].J Steroid Biochem Mol Biol,1998,64:147- 156.
  • 2Kumar N S, Richer J, Owen G,et al. Selective down regulation of progesterone receptor isoform B in poorly differentiated human endometrialcancer cells: implications for unopposed estrogen action[J].Cancer Res,1998,58:1860- 1865.
  • 3Mac Namara P, Loughrey H C. Progesterone receptor A and B isoform expression in human osteoblasts[J].Calcif Tissue Int,1998,63:39- 46.
  • 4Schmidt I U, Wakley G I, Turner R T. Effects of estrogen andprogesterone on tibia histomorphometry in growing rats[J].Calcif Tissue Int,2000,67:47 -52.
  • 5Yamamoto Y, Kurabayashi T, Tojo Y, et al. Effects of progestins on the metabolism of cancellous bone in aged oophorectomized rats[J].Bone,1998,22:533- 537.
  • 6Tang O S, Tang G, Yip I S, et al. Further evaluation on longterm depot medroxyprogesterone acetate use and bone mineral density: a longitudinal cohort study[J].Contraception,2000,62:161- 164.
  • 7Cundy T, Cornish J, Roberts H, et al. Menopausal bone loss in long term users of depot medroxyprogesterone acetate contraception[J].Am J Obstet Gynecol,2002,186:978 -983.
  • 8Gbolade B, Ellis S, Randall S. Bone density in long term users of depot medroxyprogesterone acetate[J].Br J Obstet Gynaecol,1998,105:790 -794.
  • 9Orr Walker B J, Evans M C, Ames R W, et al. The effect of past use of the injectable contraceptive depot medroxyprogesterone acetate on bone mineral density in normal post menopausal women[J].Clin Endocrinol (Oxf),1998,49:615 -618.
  • 10Cundy T, Cornish J, Roberts H, et al. Spinal bone density in women using depot medroxyprogesterone contraception[J].Obstet Gynecol,1998,92(4 Pt1):569- 573.

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