节约基因诱导重塑对治疗2型糖尿病的研究

Study of thrifty genotype on non-insulin dependent diabetes mellitus

目的 研究诱导方法 (药物的潜伏性 )在 2型糖尿病临床治疗中的作用及与化学药物 (磺脲类 )之间的关系。方法 336例 2型糖尿病患者者随机分成 3组 ,分别为中药组、西药组和中西医结合组 ,定期检测血糖及做胰岛素释放试验。结果 中西医结合组用药 3～ 6个月后 ,出现糖耐量试验右移、餐后 2h血糖正常或接近正常 ;胰岛素释放左移、峰值向 30～ 6 0min靠近。总有效率为 97%。并伴随年龄的增长存在有效性增长的趋势。结论 节约基因诱导重塑可使 2型糖尿病患者血糖调控更趋简单化 。

Objective It is to study the effect of revulsive method (latent quality of medicines) on non insulin dependent diabetes mellitus (NIDDM) and the relationship with medicines. Methods 321 patients were divided into TCM group, western medicine group and integrated group. The plasma glucose was determined terminally as well as sugar tolerance test and the insulin release test were carried out. Results Three to six months later, in the integrated group the peak value of OGTT moved right words, the level of plasma glucose tow hours after food was normal or around normal, the release of insulin moved left wards, the peak value was thirty to sixty minutes. The effective rate of integrated group was 97%. DMBG dosage and Minidlab was reduced and in some cases ceased. The efficiency tended to increase with the age. Conclusion Revulsion and rebuilding of thrifty genotype makes it ease for NIDDM to adjust and control their plasma glucose. The effect of the compounding is superior to that of the separated.