自然杀伤细胞的抗病毒活性

Antiviral responses of natural killer cells

自然杀伤细胞是一类不同于T、B淋巴细胞的多功能淋巴细胞 ,在抗病毒免疫中发挥着重要作用。目前关于自然杀伤细胞参与抗病毒反应的研究主要集中于以下 3点 :①自然杀伤细胞介导抗病毒反应的路径 ;②自然杀伤细胞受体的功能 ;③自然杀伤细胞及自然杀伤T细胞在抗病毒反应中的激活和作用机理。尽管其中仍然存在许多悬而未决的问题 。

Natural killer (NK) cells are multifunctional lymphocytes that can be distinguished from T and B cells. NK cells contribute to innate def ense during certain viral infections. Focus of recent advances in understanding the importance of NK cells in defense against viral infections is on three prima ry topics: firstly, the pathways used by NK cells to mediate antiviral defense, secondly, the functions of the nonvariant receptors and, thirdly, the activation and functions of NK cells and NK T cells. Although much remains to be learned, the mechanisms contributing to their activation and functions are being elucidat ed at the molecular level. [