饮绿茶降低吸烟、饮酒者消化系统癌发病的病例对照研究

A case-contral study on drinking green tea and decreasing risk of cancers in the alimentary canal among cigarette smokers and alcohol drinkers

目的 探讨饮绿茶是否可降低吸烟、饮酒者发生消化系统癌 (胃癌、肝癌、食管癌 )的危险度。方法 在江苏省泰兴市进行以人群为基础的病例对照研究。结果 病例为 2 0 0 0年泰兴市确诊的胃癌、肝癌、食管癌新病例且同意参加者 ,分别为 2 0 6、2 0 4、2 18例。对照为随机选取的健康人群 ,在本地居住 10年以上 ,并愿意参加者 ,共 415人。结果显示 :饮用绿茶可降低饮酒者患胃癌、肝癌、食管癌的危险度分别为 81%、78%、3 9% ,降低吸烟者患胃癌、肝癌、食管癌的危险度分别为 16%、43 %、3 1%。交互作用的检验显示饮绿茶可明显降低饮酒者患胃癌和肝癌的危险 ,交互项OR值分别为 :0 .2 3 ( 95 %CI:0 .10～ 0 .5 5 )、0 .2 5 ( 95 %CI:0 .11～ 0 .5 7)。结论 饮绿茶对饮酒者患胃癌、肝癌的危险度具有降低作用 ,还可不同程度降低饮酒者患食管癌及吸烟者患胃癌、肝癌、食管癌的危险度。

Objective To explore the role of green tea in decreasing the risks of gastric cancer, liver cancer, esophageal cancer among alcohol drinkers or cigarette smokers. Methods A population based case-control study was conducted in Taixing, Jiangsu province. Results In Taixing city,identified cases of stomach, liver and esophageal cancers were chosen with informed consent. The numbers were 206, 204, 218 respectively. Controls were chosen from normal population having lived in the area for longer than 10 years, also with informed consent. Green tea drinking seemed to have decreased 81%, 78%, 39% risk for the development of gastric cancer, liver cancer and esophageal cancer among alcohol drinkers. It might also have decreased 16%, 43%, 31% on the risks of developing the three kinds of cancers among cigarette smokers. Interaction assessment showed that drinking green tea could significantly decrease the risk of gastric cancer and liver cancer among alcohol drinkers, with ORs of interaction item 0.23 (95%CI: 0.10- 0.55) and 0.25 (95%CI: 0.11- 0.57) respectively. Conclusion Habit of drinking green tea seemed to have significant protective effects on the development of both gastric and liver cancer among alcohol drinkers while, green tea also having some protective effect on esophageal cancer among alcohol drinkers and on three kinds of cancers among cigarette smokers.