微波消解-电感耦合等离子体质谱法测定祖师麻中重金属元素含量

Determination of heavy metals content in cirald daphne bark with micorowave digestion-inductively coupled plasma mass spectrometry

采用微波消解技术建立电感耦合等离子体质谱法测定中药祖师麻中重金属Pb、Cd、Cr、As、Hg、Cu、Zn含量的方法。将样品进行微波消解,完善前处理条件,优化ICP-MS的工作参数。选取72Ge、115In、209Bi、103Rh、45Sc、6Li、159Tb、89Y作为内标元素,有效克服基体效应及仪器波动影响。采用Qcell碰撞池技术、KED模式降低了多原子干扰。测定元素标准曲线相关系数R2均在0.995以上,各元素检出限在0.003～0.193 g/L之间。用国家标准物质评价了方法准确性。研究表明,该方法线性范围宽、准确性高、精密度好,适用于快速测定不同产地的祖师麻中重金属含量,也可用于中药材的质量控制。

With microwave digestion technique, inductively coupled plasma mass spectrometry(ICP-MS) is applied to determine heavy metals such as Pb, Cd, Cr, As, Hg, Cu and Zn in Zushima(Girald daphne bark). The samples are put into microwave for digestion pretreatment to optimize parameters of ICP-MS. Elements such as 72 Ge, 115 In, 209 Bi, 103 Rh, 45 Sc, 6 Li, 159 Tb and 89 Y are selected as internal standard elements to reduce the influence of matrix and instrument fluctuations. Qcell collision cell technology and KED mode are employed to reduce polyatomic interference. The correlation coefficient R2 of the elemental standard curve is above 0.995, and the detection limit of each element is between 0.003 ~ 0.193 g/L. The accuracy of the method is evaluated by national standard materials and the results indicate that the method is with wide linear range. It is accurate and suitable for rapid determination of heavy metal content in the Zushima of different raw materials, and quality control of Chinese medicinal materials.