氧化苦参碱治疗乙型肝炎肝纤维化的临床研究

Effect of oxymatrine on hepatic fibrosis induced by hepatitis B

目的 探讨氧化苦参碱对乙型肝炎肝纤维化的临床疗效。 方法 经肝穿活组织病理检查筛选 98例乙型肝炎肝纤维化患者 ,用氧化苦参碱 10 0mlivdrip ,6个月后观察其HBVDNA定量、血清透明质酸 (HA)、层连蛋白 (LN)、PCIII及肝组织纤维化变化 ,并与 5 4例对照组进行比较。 结果 治疗组HBVDNA阴转率高于对照组 ,其HA、LN、PCIII均较对照组明显降低 ,肝组织纤维化程度明显减轻。

Objective To explore the effect of oxymatrine on hepatic fibrosis induced by hepatitis B. Methods Ninty eight patients with hepatic fibrosis induced by hepatitis B(curative group) were treated with oxymatrine.After six months of treatment, the levels of HBV DNA, serum HA,LN.PCIII and the degrees of hepatic fibrosis were examined. The above indices of 54 cases (control group) were examined too.Results The levels of HBV DNA of curative group were lower than control group.The levels of serum HA,LN and PCⅢ were reduced obviously than control group. The degree of hepatic fibrosis was modified obviously than control group. Conclusion Oxymatrine can reduce the degree of hepatic fibrosis.