黄芪水煎液对肿瘤患者放疗所致骨髓抑制的作用

Effects of radix astragali on the myelosuppression induced by irradiation in patients with cancer

目的 :探讨黄芪水煎液对肿瘤患者放疗所致骨髓抑制的作用。方法 :1 2 8例恶性肿瘤经放疗后引起骨髓抑制患者 ,随机分为试验组 (68例 )和对照组 (60例 ) ,分别应用黄芪水煎液和鲨肝醇治疗 ,观察 2组临床症状、外周血白细胞及免疫功能的变化。结果 :黄芪水煎液可明显改善临床症状 ,有效率为 1 0 0 % ,升高外周血白细胞 ,有效率为 89.7% ;对照组有效率分别为 76 .7%和 53 .3 % ,2组比较差异有统计学意义 ,P均 <0 .0 1。同时黄芪水煎液还能提高机体免疫功能 ,可明显升高患者血中Tc、Th、IgG、IgM和C3水平。结论

Aim:To study the effects of radix astragali (RA) on the myelosuppression induced by irradiation.Metheods:A total of 128 cancer patients whose WBC were low after radiotherapy were randomly allocated into 2 groups.RA extract and an antagonistic myelosuppression drug were given to the animals in the treatment group ( n =68) and the controls ( n =60), respectively. The clinical symptoms,the peripheral WBC count,and immune function were observed.Results:Compared with control group, the effective rate of improving clinical symptoms was 100%,and that of increasing WBC count was 89.7% in the treatment group, and immune function was improved with the increase of Tc,Th,IgG,IgM and C3 in blood.Conclusions:RA has antagonistic effects on the myelosuppression induced by cancer irradiation.