CSA体外干预及HLA检测与再生障碍性贫血疗效的关系

The Relationship between Clinical Effect of Medicine and Intervene Experiment of CSA in Vitro as well as Detection of HLA in Plastic Anemia

目的 :通过环孢素A(CSA)体外干预及HLA DRB1 15 0 1检测探讨其预测临床疗效的可能性。方法 :将CSA体外干预试验阳性或 /和HLA DRB1 15 0 1检测阳性者判为体外敏感 ,两者均为阴性者判为耐药。结果 :2 9例患者属体外敏感组 2 1例 ,临床治疗有效 18例 ;体外耐药组 8例 ,临床治疗有效 3例。与临床疗效总符合率80 % ,预测敏感性 85 .7% ,特异性 6 2 .4%。结论 :将CSA体外干预试验及HLA DRB1 15 0

Objective: To explore the possibility of prediction on clinical effect of medicine by intervene experiment of CSA and detection of HLA-DR B 1 *1501. Methods: The positive of intervene experiment of CSA and/or HLA-DRB 1 *1051 was judged to be sensitive in vitro and negative of them was drug resistance. Results: 21 of 29 patients were sensitive in vitro. Among them 18 cases showed good response to clinical therapy; 8 cases were resistant in vitro, in which only 3 showed effective in clinical treatment. The total coincidence with clinical effect, prediction sensitivity, specificity were 80%, 85.7%, and 62.4% respectively. Conclusion: Analysis on combination of intervene experiment of CSA in vitro and detection of HLA-DR B 1 *1501 would enhance the sensitivity of prediction in vitro on clinical effect of CSA.