霍奇金淋巴瘤潜伏膜蛋白1、p53及bcl-2蛋白的表达及意义

Expressions of latent membrane protein1,p53and bcl-2proteins and their significance in Hodgkin's lymphoma

目的探讨EB病毒潜伏膜蛋白(LMP1)、p53、bcl-2的蛋白表达在霍奇金淋巴瘤(HL)致病机制中的作用及其意义。方法对收集的31例石蜡包埋的HL组织进行LMP1、p53、bcl-2蛋白免疫组化染色。结果LMP1、p53、bcl-2的阳性率分别为58.1%、61.3%、35.5%。LMP1与p53相关性分析具有统计学意义。结论p53可能参与LMP1在HL致病机制中的作用,bcl-2可能与HL的致病关系不大。

Objective To study the expressions of latent membrane protein 1 (LMP1), p53 and bcl-2 proteins and investigate their significance in the pathogenesis of Hodgkin's lymphoma. Methods Immunohistochemical staining was used to examine the expressions of LMP1, bcl-2, and p53 proteins in 31 paraffin-embedded tissue samples from Hodgkin's lymphoma. Results The positivity rates of LMP1, p53 and bcl-2 proteins were 58.1% (18/31), 61.3% (19/31) and 35.5% (11/31), respectively, showing a statistically significant difference between the expressions of the former 2 proteins. Conclusion p53 may be in-volved as an important agent in the pathogenesis of Hodgkin's lymphoma induced by LMP1, whereas bcl-2 appears unrelated to the development of this disease.