2型糖尿病病人事件相关电位P_(300)的研究

Event-related potentials P_(300) in type 2 diabetes mellitus

目的通过对2型糖尿病患者进行事件相关电位(ERP)的检测,早期发现病人认知功能异常程度及相关因素。方法用Nicolet Viking Ⅳ型肌电图/诱发电位仪对30例2型糖尿病患者和30例年龄、性别、教育程度相匹配的健康人进行事件相关电位P300检测。对两组间ERP各参数的差异进行方差分析、t检验及Poisson分析,观察病例组ERP各参数变化与糖基血红蛋白、血脂之间的关系。结果(1)不同性别及文化程度的正常人中P300的波峰潜伏期无显著性差异(P>0.05)。(2)与正常对照组相比,2型糖尿病患者P300波峰潜伏期显著延长(P<0.01),波幅显著下降(P<0.05)。(3)2型糖尿病患者P300波峰潜伏期的延长与糖基血红蛋白、血脂的增高相关(P<0.05)。结论ERP是检测2型糖尿病患者认知功能障碍的敏感指标,有助于早期发现糖尿病患者的潜在性痴呆。

Objective To investigate event-related potentials (ERP) P 300 in patients with type 2 diabetes mellitus (DM) for ear-ly detection of the abnormalities in cognitive function and studying the related factors. Methods With the assistance of Nico-let Vinking IV equipment, ERP (P 300 ) were tested in 30 type 2 diabetic patients and 30 healthy subjects matched for age, gen-der, and education background, and the the results were analyzed statistically. The relationships of each ERP parameter with glucose hemoglobin (GHb) and blood lipid levels and renal function were analyzed. Results No significant difference was found in P 300 latencies in the control group irrespective of the gender and education (P>0.05), while the latencies were signifi-cantly prolonged (P<0.01) and the amplitudes decreased (P<0.05) in diabetic patients. It was found that P 300 correlated with glucose hemoglobin (GHb) and blood lipid levels (P<0.05). Conclusion ERP test is useful for early detection of cognition dysfunction in DM cases, helping to timely identify diabetic patients with potential dementia.