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雌、孕激素对大鼠子宫内膜NO含量的影响 被引量：2

Effect of estrogen and progestogen on nitric oxide content in rat endometrium
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摘要 目的观察乙烯雌酚、左旋18甲基炔诺酮对SD大鼠子宫内膜NO含量的影响。方法实验分为对照组、雌激素组、孕激素组,采用Griess方法测定NO含量。结果雌激素组SD大鼠子宫内膜NO含量较对照组显著升高(P<0.01),孕激素组NO含量较对照组显著降低(P<0.01)。结论雌激素、孕激素可调节子宫内膜NO含量。 Objective To observe the effect of estrogen and progestogen on the content of nitric oxide (NO) in the endometrium of SD rats. Methods Fifteen SD rats were divided into control, estrogen and levonorgestrel groups (5 in each group), with corresponding treatment indicated by the designation of the groups. The NO contents in the endometrium were determined by Griess method. Result The NO content of estrogen group was significantly higher, while that of levonorgestrel group significantly lower, than that of the control group (P<0.01 for both comparisons). Conclusion Estrogen and levonorgestrel may regulate NO synthesis in the endometrium.
作者 闸远萍
机构地区 广州军区广州总医院妇产科
出处 《第一军医大学学报》 CSCD 北大核心 2003年第3期283-283,共1页 Journal of First Military Medical University
关键词 子宫内膜 一氧化氮 乙烯雌酚 甲基炔诺酮 endometrium nitric oxide norgestrel estrogen
分类号 R711 [医药卫生—妇产科学]
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参考文献2

  • 1[1]Dunnam RC, Hill MJ, Lawson DM, et al. Ovarian hormone secretory response to gonadotropins and nitric oxide following chronic nitric oxide deficiency in the rat[J]. Biol Reprod, 1999, 60(4): 959-63.
  • 2[2]T schuggue W, Schneeberger C, Unified G, et al. Induction of inducible nitric oxide synthase expression in human secretory endometrium [J]. Hum Reprod, 1998, 13(2): 436-44.

同被引文献23

  • 1Hulboy DL, Rudolph LA, Matrlsian LM et al. Matrix metauoproteinses as mediators of reproductive function. Mol Hum Reprod, 1997, 3(1): 27-31
  • 2Zhang J, Salamonsen LA. Tissue inhibitor of metalloproteinases - 1,- 2 and - 3 in human endometrium during the menstrual cycle. Mol Hum Reprod. 1997, 3 (9) : 735-741
  • 3Lin , Kubota T, Masuda M et al. Role of nitric oxide synthase in release of endothelin from cultured human endometrial cells, Eur J Endocrinol, 1998, 138 (4): 467 -471
  • 4Zervou S, Klentzeris LD, old RW. Nitric oxide synthase expression and steroid regulation in the uterus of women with menorrhagia. Mol Hum Reprod, 1999, 5 (11): 1048-54
  • 5Walsh LS, Ollendordff A, Mershon JL. Estrogen increases inducible nitric oxide synthase gene expression. AM J Obstet Gynecol, 2003,188 (5): 1208-1210
  • 6Li XF, Ahmed A. Dual role of angiotension Ⅱ in the human endometrium, Hum Reprod, 1996, 11 : 95 - 108
  • 7Braileanu GT, Simasko SM, Speth RC et al. Angiotensin Ⅱ increases intracellular calcium concentration in pig endometrial stromal cells through type' angiotensin receptors, but does not stimulate phospholipase C activity or prostaglandin F2alpha secretion. Reprod Fertil Dev, 2002, 14 (3-4): 199-205
  • 8Casey M L, Macdonald P C. The endothelin-parathyroid homone related protein vasoacive peptide system in human endometrium: modulation by transforming gowth factor - β. Hum Reprod, 1996, 11 ( ) : 62-82
  • 9Edlund M, Andersson E, Fried G, et al. Progesterone withdrawal causes endothelin release from cultured human uterine microvascular endothelial cells. Hum Reprod, 2004, 19 (6) : 1272-1280
  • 10Tschugguel W, Schneeberger C, Unfried Get al. Elevation of inducible nitric oxide synthase activity in human endometrium during menstruation. Biol Reprod, 1999, 60 (2) : 297 -304

引证文献2

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第一军医大学学报
2003年 第3期

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