原发性结直肠癌肝转移危险因素分析

Analysis of risk factors for hepatic metastasis of colorectal carcinoma

目的初步判断结直肠癌患者肝转移的危险性。方法选择10个可能会影响肝转移的因素:患者年龄、性别、地区分布、肿瘤病理类型、部位、大小、浸润深度、侵犯肠管周径、术前癌胚抗原(CEA)水平及淋巴结转移情况,建立原发性结直肠癌肝转移危险性预测的Logistic回归模型。结果年龄、术前CEA水平和淋巴结转移情况这3个因素对肝转移影响较为显著,其回归系数分别为0.0215、0.9584和0.6404;标准误分别为0.0113、0.2740和0.2892;P值分别为0.0379、0.0005、0.0268。其他因素如浸润肠壁深度及侵犯肠管周径等对肝转移的发生也有影响,但非独立的危险因素。结论年龄、术前CEA水平和淋巴结转移情况是原发性结直肠癌肝转移的3个显著性的危险因素。

Objective To analyze risk factors for hepatic metastasis of colorectal carcinoma. Methods Ten factors which may be correlated with hepatic metastasis,including the age,sex and region of patients,the pathological type of tumors,the site and size of local lesions, the depth and circumference of invasion,the preoperative level of CEA and lymph node metastasis, were investigated and a Logistic regression analysis was established to evaluate the risk factors for hepatic metastasis of colorectal carcinoma. Results The age, preoperative level of CEA and lymph node metastasis had significant correlation with hepatic metastasis (B=0 0215,0 9584,0 6404;S =0 0113,0 2740,0 2892;P=0 0379, 0 0005, 0 0268, respectively). The hepatic metastasis rate of colorectal cancer increased with the depth and circumference of invasion, but they were not independent risk factors. Conclusions The age, preoperative level of CEA and lymph node metastasis are independent risk factors for hepatic metastasis of colorectal cancer.