前列地尔脂微球载体制剂(PGE_1)治疗肺心病心力衰竭及对肺动脉压力的影响

Efficacy of Lipo-prostaglandin E_1 on Cor Pulmonale with Heart Failure and Pulmonary Pressure

目的 观察前列地尔脂微球载体制剂 (PGE1 )对肺心病心力衰竭患者的临床疗效及对肺动脉压力的影响。方法 将 4 0例肺心病患者随机分为两组 ,治疗组 2 5例 ,在心衰的常规治疗基础上加用 PGE1 2 0μg/天 ,共 14天 ;对照组 15例 ,为心衰常规治疗。观察治疗前后各组及组间心功能分级、心率、超声心动图及肺动脉压力的变化。结果 各组治疗后较治疗前相比心功能均有不同程度的改善 ,但治疗组更为明显 ,差异有显著性。同时治疗组肺动脉压力显著降低。结论 前列地尔脂微球载体制剂对肺心病心力衰竭患者有明显疗效 ,同时能显著降低肺动脉压力 。

Objective\ To evaluate clinical therapeutic effects of lipo prostaglandin E 1(PGE 1)on Cor Pulmonale with heart failure and Pulmonary Hytertension\ Methods\ 40 patients with Cor Pulmonale were randomly divided into a treatment group(n=25,Lipo PGE 120μg/day,14days,iv drip add conventional therapy)and a control group(n=15,conventional therapy).The changes of clinical manifestation(NYHA functional class),heart rate,echocardiography and pulmonary pressure were measured before and after treatment.Results\ The improvement of NYHA class and echocardiography were significant in both group,the more significant in the treatment group,The pulmonary pressures were decreased significantly in the treatment group.Conclusion\ The effects of Lipo PGE 1 on heart failure and pulmonary pressure of Cor Pulmonale were remarkable and safety.