活性炭固载磷钨酸催化合成异丁醛缩顺-2-丁烯-1,4-二醇

Synthesis of Isobutyric Aldehyde Cis-2-Butene-1,4-Diol Acetal

研究了用活性炭固载磷钨酸催化合成异丁醛缩顺 -2 -丁烯 -1,4-二醇。考察了催化剂固载量、醇醛物质的量比、带水剂用量等因素对缩合反应的影响。其优化条件为 :顺 -2 -丁烯 -1,4-二醇、异丁醛、催化剂、带水剂的量分别为 1mol、1.0 5mol、7.0 g、10 0mL ,反应在回流温度下进行 ,时间约 3h ,收率达 86.4%。

A new synthetic method of inobutyric aldehyde cis-2-butene-1,4-diol acetal was studied.It used the phosphotungstic acid supported on activated carbon as catalyst.The effects of ratio of reactants,supported quantity and stability of catalyst and the quantity of dehydrating agent were investigated.The results showed that the optimum conditions are as follows:the amount of cis-2-butene-1,4-diol,isobulyric aldehycle,catalyst,dehydrating agent is 1mol,1.05mol,7.0g,100mL respectively;reaction temperature is reflux temperature;reaction time is about 3h.The yield is above 86.4% under the optimum conditions.Catalyst can be used repeatedly.