结扎狗小脑幕下桥静脉的实验形态学研究

EXPERIMENTAL RESEARCH OF LIGATING THE INFRATENTORIAL BRIDGING VEINS IN DOGS

模拟幕下小脑上入路(Krause入路)切断狗的幕下桥静脉,观察了狗术后一周及二周的变化。一、行为观察:术后24～48小时后狗的站立、行走、进食动作均正常,未出现共济失调等小脑病变的症状。二、组织学观察:实验一周组及二周组与正常对照组无明显区别。三、超微结构观察:实验一周组和二周组小脑半球及蚓部的颗粒细胞有较明显改变,而浦肯野细胞和分子层改变不明显。对幕下小脑上入路进行了评价并提出了手术改进的建议。

Simulated clinic operative test using the infratentoral supracerebellar approach in dogs were done and the infratentorial bridging veins were cut. After the operation the changes had been observed for one or two weeks. 1. Active changes: Standing, walking, and the action of eating were normal and the symptom of cerebellar ataxia was not found. 2. Histological changes: No obvious diference between the experimental group and the normal group was discovered. 3. Ultrastructural changes: The granule cells of the hemisphere and the vermis of the cerebellum were changed obervously between the experimental group and the normal group but Purkinje cells and molecular layer had not marked changes. We commoned on the infratentorial supracerebellar approach and made a suggestion of improving the approach.