肾综合征出血热患者的细胞免疫功能研究

Study of the cell-mediated immunity in patients with hemorrhagic fever with renal syndrome

目的研究肾综合征出血热患者的细胞免疫功能异常情况。方法应用流式细胞仪检测CD4+T淋巴细胞、CD8+T淋巴细胞。结果肾综合征出血热患者病程早期、后期与正常人比较 ,均有CD4+T淋巴细胞计数降低 (p=0.000 ,p=0.000) ,CD8+T淋巴细胞计数明显升高 (p=0.000,p=0.002) ,CD4+/CD8+ 明显降低 (p=0.000 ,p=0.000)。CD4+T淋巴细胞计数病程早期与病程后期无明显差异 (p=0.985) ,CD8+T淋巴细胞计数病程早期明显高于病程后期 (p=0.000) ,CD4+/CD8+ 病程早期明显低于病程后期 (p=0.000)。结论肾综合征出血热患者发病时存在明显细胞免疫功能异常 。

Objective To study the cellular immunity function in patients with hemorrhagic fever with renal syndrome(HFRS) Methods T lymphocytd,T Lymphocyte were determined with flow cytomeeter.Results At the earlier and later period of course, the T Lymphocyte of HFRS patients were lower than normal level(p=0.000,p=0.000),T Lymphocyte were higher than normal level(p=0.000,p=0.002),/ were lower than normal level(p=0.000,p=0.000). The T Lymphocyte at the earlier period wasn't significantly different from that in anaphase(p=0.985).TheLymphocyte was significantly higher than that in anaphase(p=0.000)./ were sighnificantly lower than that in anaphase(p=0.000). Conclusion In HFRS patients,the severe cell-mediated innunity disfunction exists at the earlier period of course,it could recover gradually at the later period of coruse.