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白介素10家族的新成员:白介素20 被引量：2

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摘要 白介素 2 0是一种新发现的细胞因子 ,属于白介素 10家族 ,其主要靶器官是皮肤 ,通过与细胞表面受体特异性结合 ,参与皮肤炎症反应。白介素 2 0的转基因小鼠表现出类似人类银屑病的症状。白介素 19、白介素 2 4、白介素 2 2与白介素 2 0的受体亚单位有交叉反应 。
作者 王妍敏 郑捷
机构地区 上海市瑞金医院皮肤科
出处 《国外医学（皮肤性病学分册）》 2003年第2期117-119,共3页 Foreign Medical Sciences(Section of Dermatology and Venereology)
基金 国家人类基因组南方研究中心资助 (编号 :CNCS 99M-12 )
关键词 银屑病 白细胞介素10 白细胞介素20 皮肤病
分类号 R392 [医药卫生—免疫学]
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参考文献20

  • 1Blumberg H, Conklin D, Xu WF, et al. Interleukin 20: discovery,receptor identification, and role in epidermal function. Cell, 2001, 104( 1 ) :9 - 19.
  • 2Gallagher G, Dickensheets H, Eskdale J, et al. Cloning, expression and initial characterization of interleukin - 19 ( IL - 19 ), a novel homologue of human interleukin - 10 ( IL - 10). Genes Immun, 2000. 1(7) :442 -450.
  • 3Dumoutier L, Louahed J, Renauld JC. Cloning and characterization of IL - 10 - related T cell-derived inducible factor ( IL-TIF), a novel cytokine structurally related to IL- 10 and inducible by IL-9. J Immunol, 2000, 164(4) :1814 - 1819.
  • 4Madireddi MT, Dent P, Fisher PB. AP - 1 and C/EBP transcription factors contribute to mda - 7 gene promoter activity during human mel anoma differentiation. J Cell Physiol, 2000, 185 ( 1 ) :36 - 46.
  • 5Soo C, Shaw WW, Freymiller E, et al. Cutaneous rat wounds express c49a, a novel gene with homology to the human melanoma differentiation associated gene, mda - 7. J Cell Biochem, 1999, 74 ( 1 ): 1 - 10.
  • 6Knappe A, Hor S, Wittmann S, et al. Induction of a novel cellular homolog of interleukin - 10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. J Virol, 2000, 74(8) :3881 -3887.
  • 7Liu Y. de Waal Malefyt R, Briere F, et al. The EBV IL - 10 homo logue is a selective agonist with impaired binding to the IL - 10 receptor. J Immunol. 1997, 158(2) :604 -613.
  • 8Beatty PR, Krams SM, Martinez OM. Involvement of IL - 10 in the autonomous growth of EBV-transformed B cell lines. J Immunol, 1997, 158(9) :4045 -4051.
  • 9Kotenko SV. Saccani S, Izotova LS, et al. Human cytomegalovirus harbors its own unique IL - 10 homolog ( cmvIL -10 ). Proc NatlAcad Sci U S A, 2000, 97(4) :1695 -1700.
  • 10OFarrell AM, Liu Y, Moore KW, et al. IL - 10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3 - dependent and -independent pathways. EMBO J, 1998. 17 (4) :1006 -1018.

同被引文献9

  • 1吕诚,赵林华,肖诚,贾红伟,查青林,闫小萍,王建明,张英泽,杨卫彬,Youwen Zhou,李梢,吕爱平.类风湿关节炎患者外周血CD4^+T淋巴细胞基因表达谱研究探讨[J].中华风湿病学杂志,2006,10(7):438-439. 被引量：10
  • 2BECKER N, NIETERS A, RITTGEN W. Single nucleotide polymorphism-disease relationships: statistical issues for the performance of association studies[J]. Murat Res, 2003,525 : 11-18.
  • 3NISHIMOTO N. Cytokine signal regulation and autoimmune disorders[J]. Autoimmunity, 2005,38 : 359 -367.
  • 4STEINER G S, MOLEN J N. Autoantibodies in rheumatoid arthritis and their clinical significance[J]. Arthritis Res, 2002,4 : S1- S5.
  • 5MIN S Y, HWANG S Y, PARK K S, et al. Induction of IL-10- producing CD4^+ CD25^+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen[J].Arthritis Res Ther,2004,6(3) :R213-R219.
  • 6BLUMBERG H, CONKLIN D, XU W F, et al. Interleukin 20 discovery, receptor identification, and role in epidermal function [J]. Cell,2001,104(1):9-19.
  • 7DUMOUTIER L, LEEMANS C, LEJEUNE D, et al. Cutting edge: STAT activation by IL-19, IL-20 and mad27 through IL-20 receptor complexes of two typesEJ]. J Immunol,2001,167(7): 3545-3549.
  • 8HSU Y H, LI H H, HSIEH M Y, etal. Function of Interleukin- 20 as a proinflammatory molecule in rheumatoid and experimental arthritis[J].Arthritis Rheum, 2006,54 (9) : 2722-2733.
  • 9SCHETT G, TOHIDAST-AKRAD M, SMOLEN J S, etal. Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c- JUNN-terminal kinase, and p38 rnitogen activated protein kinase, in synovial tissue and ceils in rheumatoid arthritis[J]. Arthritis Rheum, 2000,43 : 2501-2512.

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国外医学（皮肤性病学分册）
2003年 第2期

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