下肢动脉钙化研究进展及其对下肢动脉硬化闭塞症介入治疗的影响

Progress of lower limb arterial calcification and the impact on endovascular therapy of arteriosclerosis obliteration in lower extremity

随着人口老龄化加快,外周动脉疾病发病率逐年升高,其中以下肢动脉硬化闭塞症(ASO)最为常见,对此血管腔内介入治疗是目前临床首选治疗方法。血管钙化作为ASO的特征表现,其严重程度对介入治疗的疗效及预后均具有重要影响,与截肢及全因死亡率密切相关。正确认识并积极干预血管钙化有利于提高疗效,改善患者预后。本文主要对下肢动脉钙化的研究进展及其对下肢ASO介入治疗的影响做一综述。

With the aging of population,the prevalence of peripheral arterial disease(PAD)shows a trend of rising.Lower limb arteriosclerosis occlusion disorder(ASO)is the most common disease of PAD.Endovascular therapy is the preferred treatment for ASO in lower extremity.As the characteristic of lower limb ASO,vascular calcification has an important impact on the efficacy and prognosis of interventional therapy,which is closely related to the rates of amputation and all-cause mortality.The correct understanding and active intervention of vascular calcification are helpful for the treatment and prognosis.The advancements of lower limb arterial calcification and vascular calcification affecting endovascular therapy of ASO in lower extremity were mainly reviewed in this article.