摘要
LKB1 STK1 1基因是PJS患者的主要致病基因 ,为一种肿瘤抑制基因 ,编码一种功能未知的丝氨酸 苏氨酸蛋白激酶。LKB1基因的失活性表达以低频率事件广泛存在于全身多种肿瘤中 ,并在细胞生长抑制和p53依赖性细胞凋亡 。
出处
《国外医学（生理病理科学与临床分册）》
2003年第1期58-61,共4页
Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
参考文献20
-
1Hemminki A,Markie D,Tomlinson I, et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome [J]. Nature, 1998,391 (6663): 184-187.
-
2Jenne DE, Reimann H, Nezu J, et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase [ J ]. Nat Genet,1998,18(1): 38-43.
-
3Tiainen M, Ylikorkala A, Makela TP. Growth suppression by Lkb1 is mediated by a G ( 1 ) cell cycle arrest [ J ]. Proc Natl Acad Sci USA ,1999,96(16) :9248-9251.
-
4Karuman P, Gozani O, Odze RD, et al. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death[J]. Mol Cell,2001,7(6): 1307-1319.
-
5Ylikorkala A, Rossi DJ, Korsisaari N, et al. Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice [ J ]. Science,2001,293(5533): 1323-1326.
-
6Rowan A, Churchman M, Jefferey R, et al. In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours[J]. J Pathol,2000,192(2) :203-206.
-
7Sato N,Rosty C,Jansen M, et al. STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas[J]. Am J Pathol,2001,159(6): 2017-2022.
-
8Dong SM,Kim KM,Kim SY, et al. Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer[J]. Cancer Res, 1998,58 (17): 3787-3790.
-
9Stratakis CA. Clinical genetics of multiple endocrine neoplasias,Carney complex and related syndromes [ J ]. J Endocrinol Invest,2001,24(5 ): 370-383.
-
10Chen J, Lindblom A. Germline mutation screening of the STK11/LKB1 gene in familial breast cancer with LOH on 19p[ J]. Clin Genet,2000,57(5): 394-397.
同被引文献15
-
1葛晶,殷涌光,王凯.使用SPR生物传感器快速检测大肠杆菌E.Coli 0157∶H7[J].吉林大学学报（工学版）,2005,35(2):214-218. 被引量：19
-
2涂少华,叶元康,沈昭在.双抗体夹心ELISA检测肺炎支原体抗原方法的建立[J].检验医学,2005,20(3):214-216. 被引量：7
-
3毕春霞,闫志勇,王斌.病原微生物临床检验技术进展[J].青岛大学医学院学报,2005,41(4):369-371. 被引量：11
-
4李维彬,郭辰虹,王玉炯.病原微生物快速检测方法及研究进展[J].生物技术通报,2006,22(2):67-71. 被引量：16
-
5Gehring AG, Irwin PL, R SA, et al. Enzyme - linked immu- nomagnetic chemilumineseent detection of Eherichia coil O157: H7 J . J Inununol Methods, 2004, 293 (1 -2) : 97 -106.
-
6Ann RI, Kromholz L, Stahl DA. Fluorescent-oligonucleotide pro- bing of whole cells f)r determinative, phylogenetic, and environmental studies in micnbiolng'y E J ]. J Bterid, 1990, 172 (2) : 762 - 770.
-
7Mmhmoud KK, l_e.duc LG, Fcrroni GD. Detection of Aeidithiobacillus trrooxidans in acid mine drainage environments using fluorescent in situ hybridization (F1Stt) [ J ]. J Microbiol Methods, 2005, 61 ( 1 ) : 33 - 45.
-
8Mata AI, Gibello A, Casamayor A, et al. Muhiplex PCR assay for de- tecton of bacterial pathogens associat wilh warm - water Streptocco- sis in fish [.I ]. Appl Environ Micbiol, 2004, 70 (5) : 3183 -3187.
-
9Glukhov AI, Gordeev SA, Al'tshuler ML, el al. Use of nested PCR in detection of the plague pathogen [ J ]. Kiln Lab Diagn, 2003, ( 7 ) : 48 - 50.
-
10Boutaga K, van Winkelhoff A J, Vandenbroucke - Grauls CM, et al. Comparin of real - time PCR and culture for detection of Porphy- romonas gingivalis in subgingival plaque samples [J]. J Clin Microhi- ol, 2003, 41 (11) : 4950-4954.
-
1黎家庆,栗光明,张在兴,才文彦.血管发生对胃癌的发展与预后的影响[J].中华普通外科杂志,1999,14(3):190-192. 被引量：2
-
2吴志全.成人肝海绵状血管瘤的诊治[J].中华肝胆外科杂志,2004,10(6):361-362. 被引量：24
-
3金成,鲍传庆,许炳华.以肠梗阻为主要表现的肠血管发育异常一例[J].中华普通外科杂志,2011,26(5):445-445.
-
4张帆,郜利会,李英肖,靳福昌,宋晓丽.原发性肝癌介入化疗发现膈下动脉与肺内血管交通1例[J].河北医科大学学报,2005,26(1):50-50. 被引量：1
-
5毛红明,樊晋川,陈锦,王少新.头颈部良性血管瘤60例临床报告[J].中国冶金工业医学杂志,2002,19(1):52-53.
-
6王振军,严仲瑜,万远廉,郭燕燕,IanTomlinson,徐文怀.散发性结肠癌和卵巢肿瘤LKB1基因突变的检测[J].中华肿瘤杂志,1999,21(5):328-328.
-
7赵刚,王伟民,梁军潮.脑动静脉畸形的治疗现状[J].实用医学杂志,2005,21(21):2459-2461. 被引量：1
-
8肝血管瘤[J].医药与保健,2010(4):35-35.
-
9张春发,顾秀丽.肝血管瘤治疗方法[J].中国现代药物应用,2011,5(4):77-77. 被引量：2
-
10刘新峰,周志明.儿童脑血管病的介入治疗[J].中国小儿急救医学,2008,15(4):309-312. 被引量：1
