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人类神经元信号蛋白14-3-3在神经系统疾病诊断中的价值 被引量:2

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摘要 14-3-3是一组主要存在于真核生物细胞中的信号转导蛋白 ,近年来研究发现脑脊液中 1 4 3 3蛋白可作为一种敏感性及特异性的生物标记用于克雅氏病 (Creutzfeldt Jakobdisease,CJD)
作者 胡敏
出处 《国外医学(生理病理科学与临床分册)》 2003年第1期84-86,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金 安徽省自然科学基金:984 36 32 9
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  • 2Zivkovic S, Boada M, Lopez O. Review of Creutzfeldt-Jakob disease and other prion disease[ J]. Rev Neurol,2000, (12): 1171.
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  • 4Blennow K, Lind B, Andersson E, et al. CSF-analysis in clinical diagnosis of Creutzfeldt-Jakob disease. A literature review and three cases from routine clinical practise [ J ]. Lakartidningen, 2001,98( 20 ): 2446-2451.
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  • 7Saiz A, Marin C, Tolosa E, et al. Diagnostic usefulness of the determination of protein 14-3-3 in cerebrospinal fluid in CJD [ J ].Neurologia, 1998,13 (7)324-328.
  • 8Zerr I, Bodemer M ,Gefeller O, et al. Detection of 14-3-3 protein in the CSF supports the diagnosis of CJD[ J]. Neurology, 1997,49(2) :593-595.
  • 9Kenney K,Brechtel C,Takahashi H, et al. An enzyme -linked immunosorbent assay to quantify 14-3-3 protein in the CSF of suspected CJD patients[ J]. Ann Neurol, 2000,48 (3) :395-398.
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