1[1]Hutchison C R. Combinatorial biosynthesis for new drug discovery[J]. Cuwrent Opin Microbiol , 1998,1:319
2[2]Dhillon N,Hale R S,Cortes J, et al. Molecular characterization of a gene from Saccharopolyspora erythraea which is involved in erythromycin biosynthesis [J]. Mol Microbiol , 1989,3:1405
3[3]Donadio S, Stayer M J,McAlpine J B, et al. Modular organization of genes required for complex polyketide biosynthesis [J]. Science,1991,252: 675
4[4]Vara J, Lewandowska-Skarbek M, Wang Y G, et al. Cloning of genes govering the deoxysugar portion of the erythromycin biosynthesis in Saccharopolyspora erythraea [J]. J Bacteriol, 1989, 171:5872
5[5]Donadio S, Katz L. Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea [J] . Gene, 1992,111: 51
6[6]Hopwood D A. Forty years of genetics with Streptomyces: from in vivo through in vitro to in silico [J]. Microbiology, 1999, 145:2183
7[7]John K, Borchardt. Genetic engineering may keep one of the richest drug gold mines from being played out [ J]. Modern Drug Discovery, 1999,2:22
8[8]Sherman D H, Malpartida F, Bibb M J, etal. Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces [J]. EMBO J, 1989,8:2717
9[9]Femandez-Moreno M A, Martinez E, Boto L, et al. Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin [J]. J Biol Chem, 1992, 267:19278
10[10]McDaniel R, Ebert-Khosla S, Hopwood D A, et al. Engineered biosynthesis of novel polyketides: Influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase [J]. Proc NatlAcad Sci USA, 1994,91:11542
6Funa N,Ohnishi Y,Fujii I,et al.A new pathway for polyketide synthesis in microorganisms.Nature,1999,400:897-899.
7Kham N H,Roets E,Hoogmartens J,et al.Quantitative analysis of oxytetracycline and related substances by high-performance liquid chromatography.J.Chrom atogr,1987,405:229-45.
8Mootz H D,Schwatzer D,Marahiel M A.Ways of Assembling Complex Natural Products on Modular Nonribosomal Peptide Synthetases.ChemBioChem,2002,3:490-504.
10Menzella H G,Reid R,Carney J R,et al.Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.Nature Biotechnol,2005,23:1171-1176.
