输精管结扎术用于预防和治疗前列腺增生的实验研究

Experimental Study of Vasoligation in the Treatment and Prevention of Benign Prostatic Hyperplasia

目的 :探讨输精管及输精管静脉结扎用于预防和治疗良性前列腺增生 (BPH)的可能性及有效率。 方法 :取 5～ 6岁龄雄性杂交犬 4 0只 ,随机分为A、B、C、D 4组 ,每组 10只 ,其中A、B两组喂混合饲料制成BPH模型 ,C、D两组喂普通饲料 ,2年后将A、C两组犬的双侧输精管连同输精管静脉结扎 ,B、D两组犬仅解剖显露输精管 ,但不结扎。继续原方法饲养 2年后将 4 0只犬处死解剖出前列腺称重 ,测量体积 ,然后分组取材制片 ,观察组织学改变。 结果 :A、C两组及B、D两组前列腺重量及体积相比较 ,差异有显著性 (P <0 .0 1)。A、C两组前列腺组织切片呈退行性变而B、D两组呈增生性改变。 结论 :在BPH前行输精管及输精管静脉结扎可减轻犬在老年期的BPH ;

Objectives: To investigate the possibility and efficacy of vasoligation and deferent vein ligation in treating and preventing benign prostatic hyperplasia(BPH). Methods: 40 male pooches were divided into A, B, C and D groups randomly. Each group has 10 pooches group A and B were made into the model of BPH. Two years later, the pooches in group A and C accepted the operation of vasoligation and deferent vein ligation on both sides. Group B and D only accepted the operation of dissection and relieving its deferent duct. Then continuing to feed the 40 pooches after the operation, they were killed another two years later. After taking out their prostates and calculating their volume and weight, the sections of the prostates were checked by microscope to observe their histology and pathology changes. Results: There were significant differences of weight and volume as well as the changes of histology and pathology between group A and group C ( P < 0.01 ). It was the same with group B and D (hyperplasia changes). Conclusions: Vasoligation and deferent vein ligation before benign prostatic hyperplasia at pooches' grow up stage can reduce the extent of BPH at old age, and treatment after benign prostatic hyperplasia can make prostatic tissue appear different degrees of atrophy. Natl J Androl,2003,9(1):20 23