复合材料人工髋关节的实验研究

Experimental Study on Polysulfone Composite Hip Prosthesis

目的:应力遮挡引起的股骨上段骨吸收和远期松动是影响人工髋关节远期疗效的主要原因之一。本实验对弹性模量接近皮质骨的聚砜复合材料及其人工髋关节进行了研究。方法:用14只成年狗行右侧髋关节置换术,植入聚砚-碳纤维-羟基磷灰石复合材料假体。分术后当日、1月、3月、6月和9月组处死动物。通过单光子骨密度仪,X线摄片计算机辅助分析,光镜和扫描电镜分析,对假体植入后股骨上段骨重建变化和骨假作界面结合进行研究。结果:显示复合材料假体应力遮挡轻,假体植入侧骨密度变化与对照组相比,无骨吸收。骨假体界面结合满意,1个月结合面积(45.61±2.75)％、3个月(50.26±2.19)％、6个月(51.24±1.07)％、9个月(54.02±4.08)％。结论:聚砜复合材料假体有良好的力学相容性和生物相容性,是一种有前途的新型假体。

Objective: Cortical bone atrophy of proximal femur and prosthesis loosening secondary to stress shielding are major complications in long term result of total hip arthroplasty (THA). To solve the problem, authors developed a polysulfone composite hip prosthesis. Methods: The right hip of fourteen adult dogs were replaced with polysulfone-carbonfiber hydroxylapatite (HA) composite hip prosthesis. Animals were sacrificed on the operation day, one month, three months, six months and nine months after operation and bone remodeling of proximal femur and bone prosthesis interface integration were analyzed by single photon absorptiopmetry(SPA), computer assisted X-ray films analysis, light microscopy, fluorescent microscopy and scanning electron microscopy for histological and ultrahigh structure. Results:The composite hip prosthesis has little stress shielding and satisfaction in bone prosthesis interface integration. Bone-prosthesis integrative contact was (45. 61 ± 2. 75) % in one month, (50.26±2.19)% in three months,(51.24±1.07)% in six months and (54.02±4.08)% in nine months.Conclusion:The composite hip prosthesis has satisfactory mechanical compatibility and biocompatibility. It is a promising hip prosthesis.