2[2]Meyers PA,Heller G,Healey J,et al.Chemotherapy for nonmetastatic costeogenic sarcoma:The Memorial Sloan-Kettering experience[J].J Clin Oncol,1992,10:5~15.
3[3]Philip T,Iliescu C,Demaille MC,et al.High-dise methotrexate and HELP(holoxan,eldesine,platinum)-doxorubicin in non-metastatic osteosarcoma of the extremity:A French multicentre pilot study[J].Ann Oncol,1999,10:1065~1071.
4[4]Ohno T,Abe M,Tateishi A,et al.Osteogenic sarcoma,A study of one hundred and thirty cases[J].J Bone Joint Surg(Am),1975,57:397~404.
5[5]French Bone Tumor Study Group.Age and dose of chemotherapy as major prognostic factors in a trial of adjuvant therapy of osteosarcoma combining two altemating drug combinations and early prophylactic lung irradiation[J].Cancer,1988,61:1304~1311.
6[6]Ferrari S,Bertoni M,Mercuri M,et al.Predictive factors of disease-free survival for non-metatastic osteosarcoma of the extremity:An analysis of 300 patients treated at the Rizzoli Institute[J].Ann Oncol,2001,12:1145~1150.
7[7]Provisor AJ,Ettiger LJ,Nachman JB,et al.Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postopeerative chemotherapy:A report from the Chidren's Cancer Group[J].J Clin Oncol,1997,15:76~84.
8[8]Hudson M,Jaffe MR,Jaffe,N et al.Pediatric osteosarcoma:Therapeutic strategies,results,and prognostic factors derived from a 10-year experince[J].J Clin Oncol,1990,8:1988~1997.
9[9]Hom B,Heideman R,Geyer R,et al.A multi-institution retrospective study of intracranial ependymoma in children:Identification of risk factors[J].J Pediatr Hematol Oncol,1999,21:203~211.
10[10]Alessandri AJ,Goddard KJ,Blair GK,et al.Age is the major determinant of recurrence in pediatric differentiatited thyroid carcinoma[J].Ned Pediatr Hematol Oncol,1999,21:203~211.
7Freedman DA,Levine AJ.Regulation of the pS3 protein by MDM2 oncoprotein thirty-eighth GHA clowes memorial award lecture[J].Cancer Res,1999,59(1):1-7.
8Jaffe N.Recent advances in the chemotherapy of metastaic osteogenic sarcoma[ J].Cancer,1972,30(6):1627-1629.
9Bacci G,Lari S.Adjuvant and neoadjuvant chemotherapy in osteosarcoma [ J ].Chir Organi Mov,2001,86(4):253-268.
10Berend KR,Pietrobon R,Moore JO,et al.Adjuvant chemotherapy for osteosarcoma may notincrease survival after neoadjuvant chemotherapy and surgical resection[J] .J Surg oncol,2001,78(3):162-170.