老龄男性血清PSA检测与组织病理免疫组化研究

Study on serum PSA determination and tissues pathology immunohistochemistry

目的 以一汽集团 5 2 6名 5 0岁以上男性在职与离退休职工为受检对象 ,另以 10 1名 2 0～ 3 9岁年轻人和16名 40～ 49岁者为对照 ,研究前列腺特异性抗原 (PSA)与前列腺疾病的关系。方法 通过血清前列腺肿瘤标志物 -PSA含量测定 ,对血清PSA含量 >4 0ng/ml者与血清PSA含量正常 ,但前列腺体积明显增大伴有排尿困难者 ,采用经会阴四点穿刺取活体组织做病理与免疫组织化学分析。结果 血清PSA含量 >4 0ng/ml者占 15 0 9%。对活检的 40例病理标本检查发现 ,前列腺增生占 81 0 8%。前列腺癌的检出率为 0 95 %。结论 5 0岁以上人群Ⅱ度、Ⅲ度前列腺增生发现率 >60 %。前列腺癌的发现率约 1%。

Objective The treatise reported the PSA levels in the sera of 526 asymptomatic men(over 50 years old),16 men(age between 40-49) and 101 men(younger than 40years,control group) were determined.Methods Ninety-three men whose serum PSA levels were highere than 4.0?ng/ml were selected for biopsy.Tissues pathology analysis as well as PSA expression of prostatic tissues derived from biopsy were analyzed by methods of immunohistochemistry in biopsied men.Results Prostatic hyperplasia was 81.08% in 40 case sample,prostatic cancer was 0.95%.Conclusions The incidence rates of analysis benign prostatic hyperplasia was more than 60% and that of prostatic cancer was about 1% in men over 50 years old.