柴胡、赤芍与醋柴胡、杭白芍对大鼠高脂血症作用的实验研究

Experimental Study of Effects of Drug Couples of Bupleurum Root and Red Peony Root, Vinegar-baked Bupleurum Root and White Peony Root on Hyperlipemia in Rats

目的 :观察药对柴胡、赤芍与醋柴胡、杭白芍 ,对高脂血症大鼠脂质代谢、血小板功能影响 ,比较它们作用环节的差异。方法 :本实验采用高脂应激造成大鼠高脂血症血瘀模型方法 ,观察大鼠血瘀模型脂质代谢、血小板功能的变化。结果 :醋柴胡、杭白芍、柴胡、赤芍对TC(cholesterol)均有显著降低作用 ,醋柴胡、杭白芍强于柴胡、赤芍 ,而两者对LDL C(lowdensityli poprotein)、Lp(a) [lipoprotein(a) ]也有显著降低作用 ,但柴胡、赤芍作用较强 ,和模型组比较有明显差异 (P <0 0 5和P <0 0 1) ;醋柴胡、杭白芍对TG (triglyceride)有显著降低作用 ,和模型组比较有明显差异 (P <0 0 1) ;柴胡、赤芍对血小板聚集率和活化阳性率均有显著降低作用 (P <0 0 5 )。结论 :柴胡、赤芍与醋柴胡、杭白芍可作用于引起动脉粥样硬化的不同环节 ,柴胡、赤芍药对在抑制血小板聚集、降低血小板活化率方面优于醋柴胡、杭白芍。

Objective: To observe the effects of drug couples of Bupleurum Root and Red Peony Root(BRP), Vinegar baked Bupleurum Root and White Peony Root(VBWP) on hyperipemia in rats. Methods: The hyperlipemia and blood stasis rat model were established by high cholesterol diet and adnephrin injection. The changes of the lipid metabolism and platelet function were observed in differot groups. Results: In comparison with the control group, the VBWP and BRP groups reduced TC significatly, espesialy VBWP is more significant. Reduction in LDL C, LP (a)in these groups was found( P <0.05 or p <0.01) that they are more significant in the BRP.The VBWP groups reduced TG ( P <0.01). The VBWP groups inhibited the platelet activation and reduced the platelet aggregation ( P <0.05). Conclusions: The BRP and VBWP had different mechanisms in regulation of atherosclerosis. Further studies are needed for elucidating the mechanism.