摘要
吡啶甲醛及其衍生物广泛应用在医药、农药、新材料等领域。以5-溴-2-甲基吡啶为起始原料,通过N-氧化、氰基化、酸化、酯化、还原及氧化6步反应合成了3-溴-6-甲基-2-吡啶甲醛。所得产物经过了核磁共振(~1HNMR)及质谱(MS)验证。
Pyridine formaldehyde and its derivatives are widely used in medicine,pesticides,new materials and other fields.In this study,3-bromo-6-methyl-2-picolinaldehyde was synthesized from 5-bromo-2-methylpyridine by six steps of N-oxidation,cyanation,acidification,esterification,reduction and oxidation.The synthetic route was confirmed by the results of^1HNMR and MS.
作者
顾准
王杨
GU Zhun;WANG Yang(Suzhou Chien-Shiung Institute of Technology,Taicang 215411,China)
出处
《精细与专用化学品》
CAS
2019年第4期29-32,共4页
Fine and Specialty Chemicals
基金
苏州健雄职业技术学院"三级联动"科研基金项目自然科学类(2017SJLD14)
太仓市基础研究计划项目(TC2016YYJC09)
关键词
吡啶甲醛
氰基化
IBX氧化
pyridine formaldehyde
cyanation
oxidation by IBX
