STERIC MAPPING OF BIOLOGICAL RECEPTORS——THE SIBIS ALGORITHM AND APPLICATION

<正> Ⅰ. INTRODUCTION In a previous paper one of us has introduced the Steric Difference method which allows to compute the sterie features of the biological receptor. The derived SD~*=[SD_c~*; SD_w~*] sterie parameters are easily accessible, applicable both to congener and non-congener series and distinguishable among enantiomers and stereoiso-