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SYNTHESIS OF ETHYL 2,4-DI-(N-METHYL-2-OXO-3-INDOLYL)-BUTYRATE

SYNTHESIS OF ETHYL 2,4-DI-(N-METHYL-2-OXO-3-INDOLYL)-BUTYRATE
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摘要 Ⅰ. INTRODUCTION In a previous communication, the synthesis of some 2-oxo-3-indolyl derivatives has been reported. Ballantine et al. found that the reaction of ethyl 2-(2-oxo-3-indolylidene)-2-hydroxyacetate with propionic anhydride in the presence of pyridine furnished a red-brown crystalline product which was established as 3,4-dimethyl-2, 5-di-(N-propionyl-2-oxo-3-indolylidene)-2, 5-dihydrofuran. Similarly, treatment of isatin with ammonia furnished isamic acid.
机构地区 Faculty of Pharmacy
出处 《Chinese Science Bulletin》 SCIE EI CAS 1984年第2期272-275,共4页
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