摘要
Octapeptide cholecystokinin (CCK-8), one of the highest content neuropeptides in the brain, seems to play a complicated regulatory role in many physiological functions, among which is the modulation of pain perception. CCK-8 administered centrally or peripherally, has been reported to antagonize the analgesic effect of morphine. In the present study CCK-8 was injected intracerebroventricularly (icy) or intrathecally (ith) to see whether it could influence the analgesic effect elicited by eleetroacu-
