摘要
The analgesic effect of dynorphin (dyn) at the spinal level was first reported in 1982 by Piercey et al. in mice and by Han et al. in rats. These findings have been verified by some investigators using intrathecal injection of dyn, but not with kappa receptor agonist USO, 488. In 1982, a new [Leu] enkephalin C terminal extended peptide dyn B (rimorphin) was found and the original 17-residue peptide dyn was re-
