摘要
Insulin resistance and dysregulated lipid metabolism are major causes of type 2 diabetes. Insulin and inflammatory signal pathways play key roles in insulin resistance and fat accumulation. Specifically, adapter proteins transduce signals from insulin or cytokine receptors to the downstream pathways and may contribute to insulin resistance and disordered lipid metabolism in obesity and type 2 diabetes. Here, the recent advances in understanding the roles of adapter proteins in insulin resistance and lipid homeostasis are discussed.
胰岛素抵抗和脂质代谢异常是2型糖尿病发生的主要原因.胰岛素和炎症信号通路在胰岛素抵抗和脂肪积累中起重要作用.接头蛋白可以介导胰岛素受体或炎症细胞因子受体来的信号到下游分子,因此接头蛋白会调节肥胖和2型糖尿病中的胰岛素抵抗和脂质代谢异常.本文总结和讨论了接头蛋白在胰岛素抵抗和脂质代谢平衡中的最新进展.
基金
supported by the Changbai Mountain Scholars Program of Jilin Province 2013046(to Z.C.)
the Jilin Talent Development Foundation 111860000(to Z.C.)
the National Natural Science Foundation of China Grant 31500957(to Z.C.)
the startup funds from Northeast Normal University120401204(to Z.C.)
