摘要
我国每年有98%的骨缺损患者由于缺乏理想的人工植入物而成为功能受限者,个体化植入物设计制造已经成为我国从经验医疗转型精准医疗的关键部分。聚醚醚酮(Poly-ether-ether-ketone,PEEK)材料被普遍认为是目前最为理想的个体化植入物原材料之一,然而个体化PEEK植入物的复杂结构(尤其是大尺寸植入物)需要综合考虑PEEK材料性能、制造方法的工艺特性、临床植入应用环境等多方面的交叉影响。介绍了面向大尺寸个体化PEEK植入物的精准设计方法与控性定制3D打印方法,确立了个体化植入物设计方法与制造技术的几点准则,并描述了研究技术在一例大范围胸骨肿瘤治疗上的应用过程,所设计与制造的PEEK材料一体式胸肋骨假体,最终植入患者体内,协助大尺寸缺损胸壁的重建。
Every year, 98% of patients in China become functionally restricted due to the lack of ideal individualized artificial implants. The design and manufacture methods of individualized implants has become a key factor of China's transformation from experience medicine to precision medicine. Poly-ether-ether-ketone (PEEK) material is generally considered to be one of the most ideal materials for individual implants at present. However, PEEK’s special properties, manufacturing process characteristics, and clinical application environment should be considered to build the complex structure of individual PEEK implants (especially large scale implants). Therefore, a precision design method and a control-performance 3d printing method are put forward for the individualized PEEK implants, which established some guiding principles of design and manufacturing process. A case about extensive chest wall repaired by a large-size individualized PEEK implant is described to show the specific process of the precision design and control-performance manufacturing method.
作者
李涤尘
杨春成
康建峰
王玲
黄立军
王磊
曹毅
石长全
连芩
LI Dichen;YANG Chuncheng;KANG Jianfeng;WANG Ling;HUANG Lijun;WANG Lei;CAO Yi;SHI Changquan;LIAN Qin(State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an 710049;Shaanxi Engineering Research Center for Rapid Manufacturing Technology, Xi’an 710049;Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038)
出处
《机械工程学报》
EI
CAS
CSCD
北大核心
2018年第23期121-125,共5页
Journal of Mechanical Engineering
基金
国家自然科学基金重点项目(51835010)
西安交通大学新兴学科培育与学科交叉资助项目
关键词
PEEK材料
精准设计
3D打印
控性定制
医疗临床
PEEK material
precision design
3D printing
control-performance manufacturing
clinical application