乙肝疫苗免疫人群中乙型肝炎病毒感染现状研究

Seroepidemiology of Hepatitis B Virus Infection in the Hepatitis B Vaccinated Population

目的了解江苏省某高校乙肝疫苗免疫人群中乙型肝炎病毒(HBV)的感染现况。方法采用随机抽样法,从江苏省两所高校抽取有乙肝疫苗免疫史的2,050名18岁~22岁调查者,采用ELISA方法检测乙肝病毒表面抗原(HBs Ag)和乙肝病毒表面抗体(HBs Ab)。结果调查人群中血清Hbs Ag检出为2.98%。其中,男性检出率为3.8%,显著高于女性(1.72%,P=0.007)。与城市人群相比,农村人群中Hbs Ag检出率显著升高(3.88%VS 1.67%,P=0.004)。此外,血清Hbs Ab检出率为54.44%,农村人群中Hbs Ab血清检出率高于城市(56.28%VS 51.79%,P=0.044)。结论研究结果提示:乙肝疫苗免疫人群中仍然存在HBV感染,且Hbs Ag检出率男性高于女性,农村高于城市,需要加以重视。

Objective To evaluate hepatitis B virus(HBV) infection in HBV vaccinated population in Jiangsu province. Methods A total of 2,050 persons aged from 18 to 22 years were randomly selected from two colleges in Jiangsu province. HBV surface antigen(HBs Ag) and antibody to HBs Ag(HBs Ab) were detected by commercial ELISA kit, respectively. Results Of 2,050 participants, the seroprevalence rate of HBs Ag was2.98%; 3.8% of males' HBs Ag was positive, which was significantly higher than that of females(1.72%,P=0.007). Participants original from rural areas had higher seropositivity of HBs Ag than those original from urban areas(3.88% VS 1.67%, P=0.004). In addition, the seropositivity of HBs Ab was 54.44% among this study group and the same pattern was seen that the seropositivity of HBs Ab of participants original from rural areas was significantly higher than that of participants original from urban areas. Conclusion HBV infection in hepatitis B vaccinated immunized population should be given more attention, especially in for males and those original from rural areas.