基于CT数据构建修复髋臼骨/软骨缺损多孔钛/钢板一体化支架研究

The design of porous titanium alloy/plate scaffolds for repairing acetabular bone/cartilage defects based on CT data

目的探讨基于CT连续断层图像数据,应用Mimics软件对髋关节缺损区域进行建模,应用3D打印技术构建多孔钛/钢板一体化支架的技术要点。方法获取中国医科大学附属盛京医院收治的1例髋臼后壁粉碎性骨折合并严重骨缺损患者的CT连续断层图像的DICOM格式文件,将格式文件导入Mimics软件中,应用阈值分割、区域增长等图像分割方法,重建目标蒙板的三维模型;再结合镜像技术、布尔运算,获取重建髋臼缺损区域数字模型,以STL格式文件保存,将STL格式文件导入Magics软件中,应用计算机辅助设计构建具有特定内部结构支架的三维数字模型,并借助3D打印技术制备以Ti6Vl4V为原材料的三维骨组织工程支架;最后于支架关节面复合氮化钛生物陶瓷涂层。结果 Mimics软件成功重建出匹配程度良好的支架三维数据模型,3D打印技术成功构建出与骨/软骨缺损区域完美契合的、复合氮化钛生物陶瓷涂层的、具备特定内部结构的三维多孔钛/钢板一体化支架。结论基于CT连续断层图像数据,重建三维多孔钛/钢板一体化支架复合氮化钛涂层为临床治疗创伤性髋臼骨/软骨缺损提供了一种新的选择。

Objective To investigate the technical key points of using Mimics software to model the defect area of the hip joint based on CT continuous tomography data and using 3D printing technology to construct the integrated stent of porous titanium alloy/steel plate.Methods The DICOM format files of CT images of 1 case of comminuted posterior acetabular wall fractures with bone defect were obtained and imported into Mimics software.The image segmentation methods such as threshold segmentation and region growth were used to reconstruct the 3D model of target mask.The bone tissue engineering scaffolds model of bone defects were obtained and saved in STL format.The STL format file was imported into the Magics software,the computer assisted design(CAD)was used to construct the digital model of the three-dimensional bone tissue engineering scaffolds with a specific internal structure and and the three-dimensional scaffolds was prepared with Ti6Vl4V powder via using the 3D printing technology,followed by titanium nitride coating on its articular surface.Results The 3D data model of the scaffold was successfully reconstructed with a good matching degree by the Mimics software,and the 3D printing technology successfully constructed the 3D porous titanium alloy/steel plate integrated scaffold with specific internal structure,which perfectly matched the bone/cartilage defect area and was coated with titanium nitride bioceramics.Conclusion Reconstruction of porous titanium alloy stent/plate scaffolds with titanium nitride coating based on continuous CT images data provides a new option for clinical treatment of traumatic acetabular bone/cartilage defects.